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GlossaryVitamin D Analogues

synthetic compounds mimicking natural Vitamin D effects in treatments

Vitamin D Analogues, also known as Vitamin D Derivatives, are synthetic compounds designed to mimic the effects of natural Vitamin D in the body. They are often used in medical treatments to regulate calcium and phosphate metabolism, and are particularly useful in managing conditions like psoriasis and certain types of alopecia, where they help modulate the immune response and promote healthy skin and hair growth.

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Differential Activity of 2-Methylene-19-Nor Vitamin D Analogs on Growth Factor Gene Expression in Rhino Mouse Skin and Comparison to All-Trans Retinoic Acid

research Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid

2 citations , November 2017 in “PloS one”

Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.

Vitamin D Deficiency in Patients With Alopecia Areata and Responsiveness to Vitamin D Analogues: A Systematic Review

research VITAMIN D DEFICIENCY IN PATIENTS WITH ALOPECIA AERATA, AND RESPONSIVENESS TO VITAMIN D ANALOGUES: A SYSTEMATIC REVIEW

January 2024 in “Journal of advanced research in Medical and Health science”

People with severe and long-lasting alopecia areata often have low vitamin D levels, and treatments with vitamin D-like substances might help.

research Deficiency Pattern and Responsiveness in Clinical Settings in Discovering the Correlation between Vitamin D Analogues and Hair Growth in Alopecia Areata

March 2023 in “Pakistan Journal of Medical & Health Sciences”

Vitamin D analogues can significantly help hair regrowth in Alopecia Areata patients.

research Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.

August 2025 in “PubMed”

Vitamin D3 helps treat mild to moderate alopecia areata, especially when combined with other treatments.

Treatment of Alopecia Totalis, Universalis, and Focalis with Vitamin D and Analogs: Three Case Reports and a Literature Review

research Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review

3 citations , November 2021 in “World Journal of Clinical Pediatrics”

Vitamin D might help treat some types of hair loss, but more research is needed.

research Topically active vitamin D3 analogue, 1α,24-dihydroxy-cholecalciferol, has an anti-proliferative effect on the epidermis of guinea pig skin

16 citations , October 1987 in “British journal of dermatology/British journal of dermatology, Supplement”

A vitamin D3 compound can reduce skin cell growth.

research Vitamin D and the skin: Focus on a complex relationship: A review

139 citations , February 2014 in “Journal of Advanced Research”

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

research Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets due to a Mutation Causing Multiple Defects in Vitamin D Receptor Function

67 citations , August 2004 in “Endocrinology”

A specific gene mutation causes vitamin D resistance, but certain vitamin D analogs might help.

research Vitamin D‐dependent rickets type I and type II

57 citations , August 1997 in “Pediatrics International”

VDDR I and II are genetic disorders affecting vitamin D use, causing rickets, with VDDR I treatable by vitamin D supplements and VDDR II needing high doses and calcium.

research Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy.

14 citations , January 2019 in “PubMed”

Vitamin D might be involved in the development of alopecia areata and could help in its treatment.

research Update on the role of vitamin D in the pathogenesis of Female pattern hair loss

June 2024 in “Sohag Medical Journal”

Vitamin D is linked to hair health, but more research is needed for its use in treating female hair loss.

research Peran Vitamin D dalam Kesehatan Kulit

February 2021 in “Cermin Dunia Kedokteran”

Vitamin D helps protect skin from aging and can improve hair growth.

research Ligand-Independent Actions of Vitamin D Receptor

December 2017 in “Elsevier eBooks”

The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.

research PO-0071 Role Of Growth Hormone Therapy In Clinical, Laboratory, Radiological Improvement Of Children With Vitamin-d Dependent Rickets Type-2

October 2014 in “Archives of Disease in Childhood”

Growth hormone therapy can improve symptoms and growth in children with Vitamin-D Dependent Rickets Type-2.

research The future of vitamin D in dermatology.

12 citations , September 1997 in “PubMed”

Vitamin D could be important for many skin functions and synthetic versions may treat various skin diseases.

research Vitamin D and skin diseases: A review

48 citations , January 2015 in “Indian Journal of Dermatology, Venereology and Leprology”

Vitamin D is important for skin health and can help treat psoriasis, atopic dermatitis, and vitiligo.

research The Role of Vitamin D in Non-Scarring Alopecia

32 citations , December 2017 in “International Journal of Molecular Sciences”

Low vitamin D might be linked to certain types of hair loss, and supplements could help, but more research is needed.

research Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia

20 citations , May 2016 in “Journal of Cosmetic Dermatology”

Low vitamin D receptor levels found in hair loss patients; topical vitamin D treatment suggested.

research 975 Antifibrogenic activities of novel vitamin D3 analogs are dependent on VDR expression in human fibroblasts

April 2019 in “Journal of Investigative Dermatology”

New vitamin D3 forms need the vitamin D receptor to reduce fibrosis in human cells.

Effects of 1α,25-Dihydroxy-Vitamin D3 and Calcipotriol on Organotypic Cultures of Outer Root Sheath Cells: A Potential Model to Evaluate Antipsoriatic Drugs

research Effects of 1?,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsoriatic drugs

10 citations , October 1993 in “Archives of dermatological research”

Vitamin D compounds may help treat psoriasis by promoting skin cell differentiation.

research The skin as an endocrine organ

75 citations , September 2009 in “Dermato-endocrinology”

The skin produces and processes hormones, affecting both local and overall body functions.

research Successful Treatment of Alopecia Areata with Topical Calcipotriol

51 citations , January 2012 in “Annals of dermatology/Annals of Dermatology”

A boy with alopecia regrew hair using a vitamin D cream after other treatments failed.

research Successful etanercept therapy in therapy refractory acrodermatitis continua suppurativa Hallopeau

20 citations , May 2007 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft”

Etanercept effectively treated a severe skin condition when other treatments failed.

research ADVANCES IN PSORIASIS THERAPY

20 citations , January 2000 in “Dermatologic Clinics”

New psoriasis treatments are effective but come with side effects and risks.

research Erosive pustular dermatosis of the scalp: causes and treatments

13 citations , June 2020 in “International Journal of Dermatology”

A rare scalp condition mainly in older women can be treated with various alternatives to steroids, which may have fewer side effects.

research Topical Treatments for Scalp Psoriasis

12 citations , January 2008 in “Drugs”

Some topical treatments like corticosteroids and vitamin D analogues are effective for scalp psoriasis, but more long-term data is needed.

research Alopecia - the search for novel agents continues

11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

research An Update on Scalp Psoriasis

2 citations , January 2009 in “Actas Dermo-Sifiliográficas”

Scalp psoriasis treatments like strong corticosteroids and vitamin D3 analogues are effective, especially when combined.

Comparing the Efficacy of Combined Intralesional Triamcinolone Acetonide With Topical Calcipotriol Versus Intralesional Triamcinolone Acetonide Monotherapy in Scalp and Beard Alopecia Areata: Results From a Randomized Single-Blinded Clinical Trial

research Comparing the Efficacy of Combined Intralesional Triamcinolone Acetonide With Topical Calcipotriol Versus Intralesional Triamcinolone Acetonide Monotherapy in Scalp and Beard Alopecia Areata: Results From a Randomized Single-Blinded Clinical Trial

January 2025 in “Journal of Cutaneous Medicine and Surgery”

The combination treatment was more effective for scalp hair regrowth but caused more irritation.

research Clinical Snippets

April 2005 in “Journal of Investigative Dermatology”

Vitamin D helps protect skin, PSORS1 gene's risk interval for psoriasis is expanded, hair follicles can be generated from mouse cells, and interferon-γ may cause pigmented skin lesions.