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GlossaryVitamin D Receptor

protein that binds vitamin D to regulate gene expression

The Vitamin D Receptor (VDR) is a protein found in various cells throughout the body that binds to vitamin D, allowing it to regulate the expression of specific genes. This receptor plays a crucial role in maintaining calcium and phosphate balance, which is essential for healthy bone formation, and it also influences immune system function and hair follicle cycling.

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research Lentinula edodes (Shiitake) extract as a vitamin D receptor activator to enhance skin adaptogenic responses

August 2026 in “Scientific Reports”

This study explores the effects of an oil-soluble extract from Lentinula edodes (Shiitake), standardized for ergosterol content, on skin health. The extract, SMosE, was shown to enhance vitamin D receptor-dependent transcription in human keratinocytes and dermal fibroblasts, promoting wound repair and improving skin barrier function. Ex vivo experiments confirmed increased levels of cytokeratin 10 and claudin-1, indicating enhanced epidermal maturation. A clinical trial with 39 adults demonstrated that SMosE improved skin hydration, reduced transepidermal water loss, and regulated sebum levels after 28 days of use. These findings suggest that SMosE could be a promising ingredient for dermatological and cosmetic applications.

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

28 citations , January 2012 in “Biological & pharmaceutical bulletin”

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

research Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells

17 citations , April 2007 in “Kidney international”

Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.

Stress-Induced c-Jun-Dependent Vitamin D Receptor Activation Dissects the Non-Classical VDR Pathway from the Classical VDR Activity

research Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity

31 citations , January 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

research The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes

56 citations , September 2014 in “Molecular Endocrinology”

Vitamin D receptor is essential for hair growth signaling.

research Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-β Signaling during the Inflammatory Response to Cutaneous Injury

56 citations , November 2012 in “Endocrinology”

Vitamin D receptor is essential for proper skin healing after injury.

research Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate

1 citations , June 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Vitamin D helps skin stem cells heal wounds by working with a key skin protein.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis

144 citations , December 2004 in “Molecular Endocrinology”

The vitamin D receptor is essential for normal hair growth, even without its usual binding.

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations , November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

research Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers

11 citations , November 2021 in “JBMR plus”

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

research Evidence for 1,25-Dihydroxyvitamin D3-independent Transactivation by the Vitamin D Receptor

36 citations , February 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

The vitamin D receptor can work without its usual activating molecule.

research 698 Effect of lithocholic acid as a ligand of vitamin D receptor on hair growth in alopecia

April 2016 in “Journal of Investigative Dermatology”

Lithocholic acid helps hair growth and regeneration in alopecia by activating vitamin D receptors.

research The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D3

37 citations , August 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

The vitamin D receptor can regulate genes and affect hair and hormone levels without its usual activator.

research The role of nuclear hormone receptors in cutaneous wound repair

68 citations , December 2014 in “Cell Biochemistry and Function”

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

research Vitamin D metabolism and function in the skin

185 citations , June 2011 in “Molecular and cellular endocrinology”

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Molecular Docking of Vitamin D3 Receptor with Potential Herbal Substances as Ligands to Prevent Excessive Hair Loss in Menopausal Women

research Molecular docking of Vitamin D3 Receptor (VDR) with potential herbal substance as ligand to prevent excessive hair loss in menopausal women

August 2022 in “Indonesian Journal of Medical Chemistry and Bioinformatics”

Certain herbal compounds might help prevent hair loss in menopausal women by activating Vitamin D receptors.

research Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice

13 citations , February 2016 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Mice without active or present vitamin D receptors maintain normal blood sugar control and islet gene expression when calcium levels are normal.

research The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

127 citations , January 2008 in “PloS one”

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

Cloning of a Functional Vitamin D Receptor from the Lamprey, an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

104 citations , May 2003 in “Endocrinology”

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

research The Vitamin D Receptor as Tumor Suppressor in Skin

55 citations , January 2020 in “Advances in experimental medicine and biology”

Vitamin D and its receptor may help prevent skin cancer.

research The Tumor Suppressor Actions of the Vitamin D Receptor in Skin

9 citations , October 2014

Vitamin D receptor helps prevent skin tumors.

research Vitamin D receptor is essential for normal keratinocyte stem cell function

143 citations , May 2007 in “Proceedings of the National Academy of Sciences”

Vitamin D receptor is crucial for normal hair growth and preventing hair loss.

research Mutations in the vitamin D receptor gene in four patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets

24 citations , November 2008 in “Arquivos Brasileiros de Endocrinologia & Metabologia”

Four patients with a type of rickets and hair loss had different mutations in their vitamin D receptor gene, causing it to not work properly.

research The Role of the Vitamin D Receptor in the Epidermal Stem Cell Response to Wounding

August 2024 in “Receptors”

Vitamin D receptor is crucial for skin wound healing.

research The Role of Vitamin D and Its Receptor in Hair Follicle Biology

December 2017 in “Elsevier eBooks”

Vitamin D receptor is crucial for hair growth, not vitamin D itself.

research The Tumor Suppressor Actions of the Vitamin D Receptor in Skin

August 2013

Vitamin D receptor helps prevent skin tumors.

research Faculty Opinions recommendation of The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis.

April 2008 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

The vitamin D receptor helps control hair growth and may protect against certain skin tumors.

Immunological Aspects and Gender Bias During Respiratory Viral Infections Including Novel Coronavirus Disease-19 (COVID-19): A Scoping Review

research Immunological aspects and gender bias during respiratory viral infections including novel Coronavirus disease‐19 (COVID‐19): A scoping review

11 citations , May 2021 in “Journal of Medical Virology”

Men are more likely to have severe respiratory viral infections like COVID-19 due to hormonal and genetic differences, while women generally have stronger immune responses.

research Role of vitamin D and calcium signaling in epidermal wound healing

15 citations , August 2022 in “Journal of endocrinological investigation”

Vitamin D and calcium are important for quick and effective skin wound healing.