25 citations
,
May 2016 in “Molecular biology of the cell” A protein in plants needs to bind two lipids to help with root hair growth, and this process is similar across different plant species.
220 citations
,
August 2007 in “Journal of Bone and Mineral Research” Wnt signaling is crucial for bone regeneration.
39 citations
,
December 1998 in “Journal of Cell Science” The LEF-1 binding site enhances gene expression in hair follicles, with other proteins aiding specific regulation.
133 citations
,
February 2019 in “PLoS Biology” Feather patterns in birds are shaped by signaling interactions and cell movements, with EDA/EDAR crucial for pattern formation.
3 citations
,
August 2023 in “Genes” The document concludes that various signaling pathways and genetic factors are crucial for chicken feather development, affecting poultry quality.
8 citations
,
January 2022 in “Current topics in developmental biology/Current Topics in Developmental Biology”
27 citations
,
July 2017 in “Scientific Reports” N-WASP is essential for healthy skin and preventing inflammation.
39 citations
,
January 2013 in “Journal of Investigative Dermatology” Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
April 2023 in “Advanced functional materials” The study created a tool that mimics natural cell signals, which increased cell growth and could help with hair regeneration research.
April 2016 in “Journal of Investigative Dermatology” Decreasing MIG6 can increase the movement and invasiveness of MEK-inhibited mutant NRAS melanoma, particularly when stimulated by EGF.
January 2022 in “Stem cell biology and regenerative medicine” New hair can grow at wound sites, which could help improve treatments for hair loss and wound healing.
November 2011 in “Molecular Cancer Therapeutics” The Hedgehog signaling pathway is linked to cancer development, and targeting it with inhibitors shows promise but faces challenges like resistance.
1 citations
,
January 2015 ERK activation spreads between cells, influencing cell division and wound healing.
58 citations
,
February 2013 in “Journal of Biological Chemistry” LGR5 mainly stays inside cells, moving to the trans-Golgi network, and this process is important for its role in cell signaling.
Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.
May 2018 in “Journal of Investigative Dermatology” Activating Wnt in skin cells controls the number of hair follicles by directing cell movement and fate.
July 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” A new Wnt surrogate specifically targets the Frizzled7 receptor, promoting organoid formation and hair growth.
3 citations
,
December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Disrupting YAP signaling in skin cells leads to scar-free healing directed by specific cell signals.
44 citations
,
June 2023 in “Cell Reports” IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.
36 citations
,
June 2021 in “Experimental & Molecular Medicine” Targeting Hedgehog signaling may help treat ligamentum flavum fibrosis.
Par3–mInsc and Gαi3 work together to ensure proper cell division orientation in skin development.
Meis2 is essential for whisker development, independent of nerve involvement.
7 citations
,
October 2018 in “BMC genomics” Key genes can rewire networks, changing skin appendage types.
260 citations
,
June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
260 citations
,
December 2012 in “Cold Spring Harbor Perspectives in Biology” Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.
16 citations
,
March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.
56 citations
,
January 2022 in “Burns & Trauma” WNT5A contributes to keloid scars by promoting cell changes through specific signaling pathways.
6 citations
,
December 2022 in “Cold Spring Harbor Perspectives in Biology” Combining biochemical, immune, and mechanical signals can improve skin regeneration.
60 citations
,
July 2011 in “Stem Cells and Development” Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.
161 citations
,
August 2012 in “Seminars in cell & developmental biology” Hair growth and development are controlled by specific signaling pathways.