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GlossaryWNT gene family

group of genes producing proteins for cell signaling pathways

The WNT gene family consists of a group of genes that produce proteins involved in signaling pathways crucial for cell growth, development, and differentiation. These pathways play a significant role in various biological processes, including embryonic development and the regulation of hair growth, making them important in both normal physiology and disease states like cancer and alopecia.

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Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

research Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia

June 2023 in “Frontiers in Medicine”

Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

research Molecular Evolution and Protein Structure Variation of Dkk Family

3 citations , September 2023 in “Genes”

Dkk genes evolved faster in birds and reptiles, affecting hair development functions.

research Roles of jumonji and jumonji family genes in chromatin regulation and development

178 citations , May 2006 in “Developmental Dynamics”

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research Molecular mechanisms of ectodermal dysplasia syndromes

3 citations , June 2004 in “Työväentutkimus Vuosikirja”

Ectodermal dysplasia syndromes are caused by disruptions in key signaling pathways affecting tooth and hair development.

research Molecular cloning and characterization analysis of LEF-1 gene from Inner Mongolia Cashmere Goat

1 citations , October 2010 in “2010 3rd International Conference on Biomedical Engineering and Informatics”

The LEF-1 gene in cashmere goats was successfully cloned and analyzed, showing potential for improving cashmere production.

research APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

199 citations , April 2010 in “Nature”

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

research Transcriptomic Analysis Provides Molecular Insights into Skin Development in Dezhou Donkey Foals

January 2026 in “Veterinary Sciences”

Skin maturation in Dezhou donkey foals involves better barrier function, hair growth, and less collagen production.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.

research Recessive Mutation in FAM83G Associated with Palmoplantar Keratoderma and Exuberant Scalp Hair

10 citations , November 2017 in “Journal of Investigative Dermatology”

A mutation in the FAM83G gene is linked to skin and hair abnormalities in two related individuals.

Interplay Between EDA-EDAR and WNT Signaling Pathways in the Development of Skin Appendages in Hypohidrotic Ectodermal Dysplasia

research Interplay between EDA-EDAR and WNT signalling pathways in the development of skin appendages in hypohidrotic ectodermal dysplasia

1 citations , April 2025 in “Pediatria i Medycyna Rodzinna”

Restoring EDA and WNT pathways early may help improve skin, hair, and teeth issues in hypohidrotic ectodermal dysplasia.

research Wnt target gene Ascl4 is dispensable for skin appendage development

January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gene Ascl4 is not necessary for the development of hair, teeth, or mammary glands.

research Deficiency in Nucleotide Excision Repair Family Gene Activity, Especially ERCC3, Is Associated with Non-Pigmented Hair Fiber Growth

10 citations , May 2012 in “PloS one”

Low ERCC3 gene activity is linked to non-pigmented hair growth.

research Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development

25 citations , September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

research Hairless triggers reactivation of hair growth by promoting Wnt signaling

137 citations , September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep

research Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep

23 citations , May 2020 in “Cell Death and Disease”

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

research TGFβ family mimetic peptide promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 mice

9 citations , August 2018 in “Biomedical dermatology”

A peptide called DPS-1 helps human scalp cells grow and stimulates hair growth in mice.

Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

research Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways

27 citations , April 2017 in “British Journal of Dermatology”

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

research CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth

15 citations , July 2016 in “Biochemical Journal”

Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.

research Marie Unna hereditary hypotrichosis: A Turkish family with loss of eyebrows and a U2HR mutation

11 citations , September 2010 in “American Journal of Medical Genetics - Part A”

A Turkish family with sparse hair and eyebrow loss has a mutation in the U2HR gene linked to Marie Unna hereditary hypotrichosis.

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

74 citations , September 2006 in “Cell Cycle”

The HR protein's role as a repressor is essential for controlling hair growth.

research In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators

173 citations , January 2014 in “Nature Cell Biology”

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

research In silico analysis of gene expression data from bald frontal and haired occipital scalp to identify candidate genes in male androgenetic alopecia

6 citations , September 2019 in “Archives of Dermatological Research”

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.

research Expression of the Wnt signaling pathway and hair follicle development in Rex rabbits of different ages

April 2025

Rex rabbits should not be slaughtered before 120 days for the best fur quality.

research Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

77 citations , June 2007 in “PLoS ONE”

Birds can regenerate inner ear cells using specific gene pathways, unlike mammals.

research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

11 citations , January 2018 in “Acta dermato-venereologica”

Researchers found specific genes in the part of hair follicles that could help treat hair disorders.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)

6 citations , May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

research Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: a follow-up report

May 2018 in “European Journal of Dermatology”

The first Japanese family with Marie Unna hereditary hypotrichosis showed hair condition improvement in a child and highlighted the risk of misdiagnosis.

research Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs

14 citations , October 2000 in “Genomics”

Rat dermal papilla cells have unique genes crucial for hair growth.

Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

research Transcriptome Dynamics Reveal Stage-specific and Melatonin-triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

June 2021 in “Research Square (Research Square)”

Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.