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GlossaryWnt10b

protein crucial for activating hair follicle stem cells

Wnt10b is a protein that plays a crucial role in the regulation of hair growth and development. It is part of the Wnt signaling pathway, which is essential for various cellular processes, including cell proliferation, differentiation, and migration. In the context of hair, Wnt10b helps to activate hair follicle stem cells, promoting the growth of new hair.

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WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

research WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

197 citations , June 2009 in “American journal of human genetics”

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

research WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation

96 citations , June 2017 in “Nature Communications”

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

77 citations , July 2012 in “Journal of Investigative Dermatology”

Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.

research Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth

61 citations , June 2014 in “Scientific Reports”

Wnt1a-conditioned medium from stem cells helps activate cells important for hair growth and can promote hair regrowth.

research WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma

55 citations , March 2015 in “Carcinogenesis”

WNT10A helps esophageal cancer cells spread and keep renewing themselves.

research The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles

35 citations , February 2019 in “Cell Communication and Signaling”

BMP6 and Wnt10b control whether hair follicles are resting or growing.

research Wnt10b Promotes Differentiation of Mouse Hair Follicle Melanocytes

29 citations , January 2013 in “International Journal of Medical Sciences”

Wnt10b helps hair follicle cells mature and produce pigment.

research The role of WNT10B in physiology and disease: A 10-year update

27 citations , February 2023 in “Frontiers in Cell and Developmental Biology”

WNT10B is important for body functions and linked to diseases like osteoporosis, obesity, and cancer.

Promotion of Hair Follicle Development and Trichogenesis by Wnt-10b in Cultured Embryonic Skin and Reconstituted Skin

research Promotion of hair follicle development and trichogenesis by Wnt-10b in cultured embryonic skin and in reconstituted skin

27 citations , May 2006 in “Biochemical and Biophysical Research Communications”

Wnt-10b is important for starting hair growth and developing hair follicles.

research Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system

23 citations , June 2015 in “Journal of Tissue Engineering and Regenerative Medicine”

Wnt1a helps keep cells that can grow hair effective for potential hair loss treatments.

research Low-level laser treatment stimulates hair growth via upregulating Wnt10b and β-catenin expression in C3H/HeJ mice

15 citations , May 2017 in “Lasers in Medical Science”

Low-level laser treatment helps mice grow hair by increasing certain protein levels linked to hair growth.

LncRNA-PCAT1 Maintains Characteristics of Dermal Papilla Cells and Promotes Hair Follicle Regeneration by Regulating miR-329/Wnt10b Axis

research LncRNA-PCAT1 maintains characteristics of dermal papilla cells and promotes hair follicle regeneration by regulating miR-329/Wnt10b axis

13 citations , April 2020 in “Experimental Cell Research”

PCAT1 helps hair growth by controlling miR-329/Wnt10b.

research Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness

12 citations , September 2021 in “PLoS ONE”

WNT10A and EBF1 interaction affects hair growth in male-pattern baldness.

research Melatonin Regulates the Periodic Growth of Cashmere by Upregulating the Expression of Wnt10b and β-catenin in Inner Mongolia Cashmere Goats

9 citations , July 2021 in “Frontiers in genetics”

Melatonin makes cashmere grow earlier and more by increasing certain gene activity in goats.

research Immunohistochemical study of hair follicle stem cells in regenerated hair follicles induced by Wnt10b

9 citations , January 2016 in “International Journal of Medical Sciences”

Increasing Wnt10b levels can help grow new hair follicles in mice.

LncRNA-599547 Contributes to the Inductive Property of Dermal Papilla Cells in Cashmere Goats Through miR-15b-5p/Wnt10b Axis

research LncRNA-599547 contributes the inductive property of dermal papilla cells in cashmere goat through miR-15b-5p/Wnt10b axis

7 citations , August 2020 in “Animal biotechnology”

A specific RNA in cashmere goats helps improve hair growth by interacting with certain molecules.

research Expression profile analysis of dermal papilla cells mRNA in response to WNT10B treatment

7 citations , December 2019 in “Experimental and Therapeutic Medicine”

WNT10B affects hair growth by altering gene activity in hair cells.

research The fundamentals of WNT10A

6 citations , January 2025 in “Differentiation”

WNT10A is important for tissue development and linked to various human disorders.

research Narrowband UVB treatment induces expression of WNT7B, WNT10B and TCF7L2 in psoriasis skin

5 citations , May 2019 in “Archives of Dermatological Research”

Narrowband UVB treatment increases certain gene expressions in psoriasis skin and improves symptoms.

Wnt10a as a Candidate for Induction of Dental Pulp Regeneration with Dentine-Inducing Capacity

research Wnt10a Is a Candidate as a Non-Cellular Agent for Induction of Dental Pulp Regeneration with Dentine-Inducing Capacity.

3 citations , January 2023 in “Journal of Hard Tissue Biology”

Wnt10a may help regenerate dental pulp and form dentine.

research Vitamin A regulates dermal papilla cell proliferation and apoptosis under heat stress via IGF1 and Wnt10b signaling

2 citations , August 2023 in “Ecotoxicology and environmental safety”

Vitamin A helps rabbit skin cells grow and survive heat stress.

research Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases

1 citations , June 2025 in “Stem Cell Reviews and Reports”

research The Role of Wnt10b/β-Catenin Signaling Pathway in Hair Follicle Development in Different Ages of Rex Rabbits

1 citations , May 2024 in “Preprints.org”

Rex rabbit fur is best harvested at 120 days for optimal hair density and quality.

research Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

1 citations , December 2023 in “Animals”

Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.

Mutational Spectrum of EDA, EDAR, EDARADD, and WNT10A Genes in the Largest Cohort of Russian Patients With Hypohidrotic Ectodermal Dysplasia

research Mutational spectrum of EDA, EDAR, EDARADD, and WNT10A genes in the largest cohort of Russian patients with hypohidrotic ectodermal dysplasia

February 2026 in “Orphanet Journal of Rare Diseases”

Most genetic mutations causing hypohidrotic ectodermal dysplasia in Russian patients are found in the EDA gene.