research The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles
We need to study how dissolving microneedles behave in the body to use them for medicine.
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research Disruption of Botryococcus braunii colonies by glycoside hydrolases
Enzymes can release hydrocarbons from Botryococcus braunii without harming cells, suggesting potential for continuous extraction.
research Theoretical evaluation of interaction of some dibenzo derivatives on both androgen receptor and 5α-reductase enzyme
Certain Dibenzo derivatives may help treat prostate cancer.
research Gas chromatography/mass spectrometry based hair steroid profiling may reveal pathogenesis in hair follicles of the scalp
Analyzing hair with this method can help understand and monitor scalp conditions and treatment effects.
research Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis
Antizyme slows skin tumor growth by reducing cell growth in mice.
research Predicting therapeutic drugs for hepatocellular carcinoma based on tissue-specific pathways
Securinine and ajmaline may effectively treat liver cancer, with securinine being less toxic to normal cells.
research Plant-Derived Exosomes: Nano-Inducers of Cross-Kingdom Regulations
Plant-derived exosomes can help deliver drugs and enable communication between different organisms.
research Ingestion of minoxidil associated with elevated transaminases in the absence of ischemic hepatitis
Minoxidil ingestion can raise liver enzyme levels.
research Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers
Improved Finasteride delivery for hair loss treatment.
research Highly Sensitive Simultaneous Measurement of Steroid Hormone in Human Serum by Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry
A new method accurately measures nine steroid hormones in human serum with high sensitivity.
research Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss
Genetic variants affect minoxidil hair loss treatment success.
research Drug-induced postinfantile giant cell hepatitis
Certain liver diseases respond well to specific treatments and have varying risks for liver cancer.
research Functional analysis of thymosin beta-4 using over-expressing transgenic mice
Melanoma cells lose their ability to form tumors when placed in a zebrafish embryo environment.
research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis
Inhibiting ODC can prevent UV-induced skin cancer.
research Docking and Molecular Dynamics Identify Leads against 5 Alpha Reductase 2 for Benign Prostate Hyperplasia Treatment
New compounds show promise for treating benign prostate hyperplasia with fewer side effects.
research Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids
Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.
research Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
Stopping mitochondrial respiration can prevent brain cancer spread in skin cancer patients, and plant compound β-sitosterol could help achieve this.
research Attenuation of 5α-reductase-mediated progesterone metabolism promotes differentiation of human endometrial stromal cells for the establishment of pregnancy
Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.
research Genetic variants in AR and SHBG and resistance to hormonal castration in prostate cancer
Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.
research APLICAÇÃO DE PLANEJAMENTO DE EXPERIMENTOS (DoE) PARA OTIMIZAÇÃO DE MÉTODO ANALÍTICO PARA QUANTIFICAÇÃO DE MINOXIDIL POR CLAE
Optimizing the method improved minoxidil measurement accuracy and efficiency.
research Repurposing steroidogenesis inhibitors for the therapy of neuropsychiatric disorders: Promises and caveats
Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
research オルニチン・トランスカルバミラーゼ(OTC)欠損(spf・ash)マウスへのOTC遺伝子導入
Introducing the OTC gene improved symptoms in mice with OTC deficiency.
research Formulation Development, Pharmacological Evaluation, and Characterization of Eclipta alba Phytosomes
Eclipta alba phytosomes improve bioavailability and therapeutic effects.
research P381 Kinetics of Titan cells generation and transcriptome modifications comparing three in vitro protocols
Three different methods were compared for creating Titan cells, a type of fungus cell. The OZ method made the most cells initially, but the number dropped quickly. The EB method also made a lot of cells, but the number also dropped. The AA method made fewer cells, but the number stayed steady. The methods also affected which genes were active in the cells.
research Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells
research A computer‐aided drug repurposing: the antibacterial agents targeting GroEL
Daprodustat, combined with PAβN, could be a new antibacterial treatment.
research The legacy of Bruce Ames and mitochondrial DNA mutagenicity: integrating oxidative stress, aging, and modern perspectives
Bruce Ames's work has greatly influenced research on genetics, aging, and health, inspiring ongoing studies on mitochondria and longevity.
research Liposomes in cancer therapy
Liposomes show promise in cancer treatment by delivering drugs with less toxicity and improved effectiveness.
research Testosterone protects female embryonic heart H9c2 cells against severe metabolic stress by activating estrogen receptors and up-regulating IES SUR2B
Testosterone protects female heart cells from stress by activating estrogen receptors.
research Sulphate conjugation of minoxidil in rat skin
Rat skin can convert minoxidil into its active form, aiding hair growth.