June 2021 in “Asian Journal of Medical Sciences” Vitamin B12 deficiency can cause reversible skin darkening.
15 citations
,
March 1997 in “International Journal of Dermatology” Selenium sulfide in anti-dandruff shampoos can turn hair green.
17 citations
,
April 2004 in “Acta Clinica Belgica” UV light makes skin signs of lack of carotene and vitamin A more visible.
77 citations
,
August 1986 in “Archives of Dermatology” Vitamin B12 deficiency can cause skin and hair color changes, which are reversible with treatment.
17 citations
,
April 2002 in “Contact Dermatitis” Minoxidil 5% caused skin discoloration in a man using it for hair loss.
9 citations
,
May 2013 in “JAMA Dermatology” A woman's hair turned white after taking a cancer drug called dasatinib.
July 2021 in “PARIPEX INDIAN JOURNAL OF RESEARCH” Knuckle darkening can be an early sign of vitamin B12 deficiency.
2 citations
,
January 2002 in “Clinics in Dermatology” Vitiligo causes white skin patches, often starts before age 20, and is linked to other health issues.
6 citations
,
December 1989 in “Journal of the American Academy of Dermatology” Minoxidil lotion can cause hair discoloration.
16 citations
,
February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
April 2026 in “Indian Journal of Dermatology” Follicular vitiligo causes hair whitening without skin color change and can be treated for repigmentation.
January 2007 in “Journal of the American Academy of Dermatology” A 73-year-old man's grey-white hair turned dark brown after eczema treatment.
October 2021 in “QJM: An International Journal of Medicine” Vitiligo patients have higher hydrogen peroxide levels and lower E-cadherin, affecting skin cell adhesion and pigmentation.
303 citations
,
August 1971 in “The American Journal of Medicine” Melanocytes are destroyed by factors needed for melanin production, causing vitiligo and gray hair.
November 2022 in “Brazilian journal of veterinary pathology” The Yorkshire terrier has a genetic hair loss condition not improved by treatment.
August 2020 in “European Journal of Dermatology” Dutasteride for hair loss can cause skin reactions like itchy red plaques.
11 citations
,
August 1986 in “Archives of Dermatology” Vitamin B12 deficiency can cause skin and hair color changes, which can be reversed with treatment.
December 2023 in “Clinical, cosmetic and investigational dermatology” The study found that white hair in vitiligo has specific patterns and structures, which vary with the stage of the disease and may be similar to another hair condition.
July 2025 in “Pigment International” Follicular vitiligo causes hair to gray without skin color loss.
April 2016 in “Journal of The American Academy of Dermatology” A woman's skin symptoms led to a diagnosis of systemic AL amyloidosis, but she died from sepsis shortly after.
July 2002 in “Dermatologic Surgery” Some people's hair turned white or gray after using intense pulsed light for hair removal, and for some, it was permanent.
1 citations
,
September 2024 in “Journal of Oncology Pharmacy Practice” Hydroxyurea treatment unexpectedly restored hair color from gray to dark brown in an older woman.
February 2018 in “Egyptian Journal of Radiation Sciences and Applications” Patients with Discoid Lupus Erythematosus have lower vitamin D and antioxidant levels and higher oxidative stress.
63 citations
,
December 1988 in “International Journal of Dermatology” Vitiligo causes white skin patches and is linked to autoimmune issues.
10 citations
,
February 2006 in “Archives of dermatology” A man's chest hair turned white after a shingles infection, possibly due to virus-damaged pigment cells.
July 2026 in “International Journal of Applied Pharmaceutics” Hair dyes, especially with PPD, can cause skin and rare systemic reactions, and safer alternatives are needed.
119 citations
,
May 1987 in “The Journal of Dermatologic Surgery and Oncology” Most patients' skin darkening after sclerotherapy fades on its own within 6-24 months.
6 citations
,
March 2020 in “Anais Brasileiros de Dermatologia” Thyroid disease can cause skin and hair changes, treatable with levothyroxine.
March 2026 in “Indian Dermatology Online Journal” Hair dye ingredient PPD can cause severe allergic reactions, including facial swelling.
June 2022 in “Journal of Pakistan Association of Dermatologists” Vitiligo may start as small white spots in hair follicles.