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GlossarySebaceous Gland Activity

production of sebum by skin glands

Sebaceous gland activity refers to the function of sebaceous glands in the skin, which produce and secrete an oily substance called sebum. Sebum helps to lubricate and protect the skin and hair, but excessive activity can lead to oily skin and conditions like acne, while insufficient activity can result in dry skin.

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Research

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Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands

research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands

45 citations , September 1998 in “Journal of Investigative Dermatology”

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumors with a Predominant Reserve Cell Population

research Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population

5 citations , February 2015 in “Journal of Comparative Pathology”

High proliferative activity and peripheral invasion indicate malignancy in canine sebaceous gland tumors; the term 'epithelioma' should be updated for clarity.

research The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff

241 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Dandruff and seborrheic dermatitis are caused by yeast feeding on scalp oils, leading to irritation and flaking.

research Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

30 citations , April 2007 in “Dermatologic Clinics”

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

research Local stimulation of sebaceous gland activity by the topical administration of dehydroepiandrosterone

1 citations , January 1988

Topical DHEA safely increases skin oil production.

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community Could a reversed SARM designed for the scalp serve as a replacement for oral Dut and Fin?

in Finasteride/Dutasteride 2 upvotes 1 year ago

The conversation discusses the potential of developing a selective oral SARM to target androgen activity in the scalp and skin, as an alternative to oral Dutasteride and Finasteride, which have systemic side effects. It also mentions Clascoterone and RU58841 as topical treatments for hair loss.

community Hot weather causing hair shedding?

in Minoxidil 3 upvotes 8 months ago

Hot weather can increase hair shedding, possibly due to dehydration and active sebaceous glands. Using shampoos with salicylic acid or zinc pyrithione may help; daily anti-inflammatory use is not recommended.

community Why does Finasteride make my hair not get greasy fast anymore?

in Finasteride/Dutasteride 31 upvotes 2 years ago

Finasteride, a hair loss treatment, was observed to reduce scalp oiliness in users. Anti-androgens like Finasteride are known to decrease the activity of oil-producing glands.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community When you think about it blocking dht is not that big of a deal as it’s made out to be

in Research/Science 5 months ago

Reducing sebum can indirectly lower DHT levels, with treatments like accutane, tretinoin, and green tea extract acting as DHT blockers. Accutane can lower DHT levels by reducing 5α-reductase activity, but its impact on hair varies.

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learn Epidermal Growth Factor

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