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GlossaryTGFBR2

regulates cell growth and differentiation through TGF-beta signaling

TGFBR2, or Transforming Growth Factor Beta Receptor 2, is a protein that plays a crucial role in cell signaling. It is part of the TGF-beta signaling pathway, which regulates various cellular processes, including cell growth, differentiation, and apoptosis. Mutations or alterations in TGFBR2 can lead to various diseases, including cancer and fibrosis, due to its role in controlling cell behavior.

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research 1325 Age-dependent loss of the stemness and antimicrobial defense function of dermal fibroblasts is mediated by TGFbeta

April 2018 in “Journal of Investigative Dermatology”

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

research Effects of TGFBR1 on Proliferation of Dermal Papilla Cells in Fine-Wool Sheep

December 2025 in “Animals”

TGFBR1 slows down cell growth in fine-wool sheep hair follicles.

research Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

159 citations , October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages

research Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

115 citations , February 2016 in “Nature Communications”

Epidermal β-catenin activation changes the dermis by signaling different fibroblast types.

research Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

111 citations , June 2002 in “The EMBO Journal”

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

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community Group Buy for MR antagonist finerenone

in Product 11 upvotes 3 years ago

User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

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