Stress-Induced Senescence of Dermal Papilla Cells Restored by Synthesized Ceramide

September 2017

Jung Eun Kim

ceramide dermal papilla cells ERK/Akt pathway Wnt/β-catenin pathway Wnt5a β-catenin Wnt10b hair follicles senescence

TLDR Ceramide may help delay hair aging by restoring stressed hair cells.

The study investigated the effects of ceramide on stress-induced senescence of dermal papilla cells (DPCs), focusing on growth factors like ERK/Akt and Wnt/β-catenin pathways. It was found that ceramide decreased Akt phosphorylation and significantly upregulated ERK phosphorylation in H2O2-treated DPCs. Additionally, ceramide increased Wnt5a and β-catenin mRNA levels and upregulated Wnt10b expression in these cells. The results suggested that ceramide might play a role in maintaining hair follicles in environments of senescence, such as aging or damage, and could be useful in delaying hair senescence.

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