Formulation And Evaluation Of Controlled-Release Minoxidil Nanogels For Topical Application

May 2026 in “ Zenodo (CERN European Organization for Nuclear Research) ”

Pooja Singh*, Dr. Nadeem Farooqui, Nayany Sharma, Dr. Nimita Manocha

This study developed a chitosan-based minoxidil nanogel for improved topical delivery in treating alopecia. The optimized nanogel, created using ionic gelation and a Box–Behnken design, had a particle size of 135.4 nm, low polydispersity, high positive zeta potential, and 89.7% entrapment efficiency. It demonstrated skin-compatible pH, pseudoplastic rheological behavior, good spreadability, and physical stability. In vitro studies showed sustained drug release over 48 hours and better drug deposition compared to conventional minoxidil solutions, indicating its potential as an effective treatment for alopecia.

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research Formulation And Evaluation of Controlled-Release Minoxidil Nanogels for Topical Application

May 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This study focused on creating a chitosan-based minoxidil nanogel to enhance the topical treatment of alopecia by improving drug retention and targeting. The optimized nanogel, developed using the ionic gelation method and Box–Behnken design, had a particle size of 135.4 nm, a low polydispersity index, a high positive zeta potential, and an entrapment efficiency of 89.7%. It demonstrated skin-compatible pH, pseudoplastic rheological behavior, good spreadability, and physical stability. In vitro studies showed sustained drug release over 48 hours and better drug deposition compared to conventional solutions, indicating its potential as an effective treatment for alopecia.

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