Dual In Situ Integration for Braided Silk Fibers Enabling Multifunctional Bioactive Sutures

The study introduces a silk-based bioactive suture enhanced with silver nanoparticles and curcumin through a dual in situ integration strategy. This innovative suture maintains mechanical integrity while offering multifunctional benefits, including real-time wound monitoring via a colorimetric pH response, strong antibacterial and anti-inflammatory properties, and promotion of wound healing through angiogenesis and collagen deposition. The findings suggest that this approach could lead to the development of advanced smart sutures with customizable bioactivities and monitoring capabilities, addressing key challenges in surgical interventions.