Silk Fibroin Nanofibers: Advancements in Bioactive Dressings Through Electrospinning Technology for Diabetic Wound Healing

    September 2024 in “ Pharmaceuticals ”
    Afaf Aldahish, S. Nirenjen, Rajalakshimi Vasudevan, Taha Alqahtani, Saud Alqahtani, Ahmad Mohammad Asiri, D Praveen, Tamilanban Thamaraikani, Chitra Vellapandian, J. Narayanan
    TLDR Silk fibroin nanofibers may help heal diabetic wounds, but more research is needed.
    The document reviews the potential of silk fibroin nanofibers, created through electrospinning technology, as bioactive dressings for diabetic wound healing. These nanofibers are noted for their biocompatibility, biodegradability, and mechanical strength, which support essential healing processes such as tissue regeneration and angiogenesis. Silk fibroin mimics the extracellular matrix, promoting cell adhesion and proliferation, and can incorporate bioactive agents to enhance therapeutic efficacy. Despite promising preclinical and clinical results, challenges remain in optimizing formulations and validating efficacy in larger clinical trials. Future advancements in biofabrication and understanding of silk fibroin's biological interactions are expected to improve these advanced wound care applications.
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