Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages

    December 2003 in “ Experimental Dermatology ”
    Colin A.B. Jahoda, Claire J. Whitehouse, Amanda J. Reynolds, Nicholas Hole
    TLDR Hair follicle cells can become fat and bone cells.
    The study explored the potential of adult hair follicle dermal papilla (DP) and dermal sheath (DS) cells to differentiate into adipogenic and osteogenic lineages. Researchers demonstrated that these cells, when cultured, could be directed to form lipid and bone cells, indicating their potential as a source of stem cells for tissue engineering and cell therapy. Clonal DP and DS lines with extended proliferative capabilities were produced, showing varied capacities for differentiation. The study highlighted the hair follicle as a promising and accessible source of stem cells, with potential implications for understanding skin pathologies and the broader capabilities of dermal stem cells.
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