Improvement of Hair Loss by a Persimmon Leaf, Green Tea, and Sophora Fruit Extract Complex (BLH308)

August 2022 in “ Korean journal of medicinal crop science/Han-gug yagyong jagmul hag-hoeji ”

Hua Li, Moon Ho, Minjee Lee, Su‐Bin Oh, Suyeon Cho, Jong‐Moon Jeong

persimmon leaf green tea sophora fruit BLH308 antioxidant activity anti-inflammatory effects interleukin-6 tumor necrosis factor-α RAW 264.7 cells 5-alpha reductase Ⅱ human dermal papilla cells C57BL/6N mice testosterone propionate hair growth phase androgenetic alopecia IL-6 TNF-α 5-AR male pattern baldness

TLDR BLH308, made from persimmon leaf, green tea, and sophora fruit, may help reduce hair loss by fighting oxidative stress and inflammation.

The study investigated the effects of a complex extract (BLH308) made from persimmon leaf, green tea, and sophora fruit on hair loss. The extract demonstrated significant antioxidant activity and anti-inflammatory effects in vitro, including the inhibition of interleukin-6 and tumor necrosis factor-α production in RAW 264.7 cells and downregulation of 5-alpha reductase Ⅱ expression in human dermal papilla cells. In vivo tests on C57BL/6N mice with testosterone propionate-induced hair loss showed that BLH308 promoted the onset of the hair growth phase, effectively reducing hair loss. The results suggest that BLH308 could be a promising candidate for treating androgenetic alopecia.

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