In Patients With Acne Vulgaris, How Do Standard Acne Treatments Combined With Adjunct Microbiome-Targeted Therapies Compare to Standard Acne Treatments Alone in Affecting Clinical Outcomes?

The study investigates the impact of combining standard acne treatments with microbiome-targeted therapies on clinical outcomes in patients with acne vulgaris. A review of 5 studies revealed that oral probiotics as adjuncts significantly improved acne severity and lesion reduction compared to standard treatments alone. Topical probiotic formulations were as effective as 2.5% Benzoyl Peroxide in reducing inflammatory lesions and were associated with fewer side effects. Additionally, oral probiotics reduced gastrointestinal adverse events linked to Doxycycline. Overall, microbiome-targeted therapies, particularly oral probiotics, enhance both the efficacy and safety of standard acne treatments.