TLDR Multiphoton microscopy effectively images mouse skin layers and structures.
The study explored the use of multiphoton microscopy (MPM) for imaging in vivo hair mouse skin, utilizing two-photon excited fluorescence (2PEF) and second harmonic generation (SHG). The research demonstrated that MPM could effectively reveal the microstructure of the stratum corneum, stratum spinosum, and dermis, allowing for the clear identification of components such as corneocytes, spinosum cells, collagen fibers, and hair follicles. The study involved five Kunming white mice and highlighted MPM's potential as a valuable tool for investigating skin physiological and pathological states in a non-invasive manner.
53 citations
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July 2009 in “Cancer Research” Blocking certain proteins can reduce skin inflammation caused by cancer treatment.
829 citations
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May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
58 citations
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November 2013 in “Journal of Innovative Optical Health Sciences” Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
2 citations
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July 2017 in “IEEE Photonics Journal” The study found that combining SHG and OCT effectively monitors skin wound healing in mice.
1 citations
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December 2014 in “Scanning” Multiphoton microscopy effectively images rabbit skin structures in detail without staining and shows differences from human skin.
264 citations
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January 2008 in “Journal of biomedical optics” Zinc oxide nanoparticles in sunscreen do not penetrate deep into the skin.
24 citations
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September 2018 in “Lasers in Surgery and Medicine” Multiphoton microscopy can non-invasively tell apart scarring from non-scarring hair loss and could aid in treatment.
