The Potential of Nestin-Expressing Hair Follicle Stem Cells in Regenerative Medicine

    February 2007 in “ Expert Opinion on Biological Therapy ”
    Robert M. Hoffman
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    TLDR Hair follicle stem cells could help repair nerves and avoid ethical issues linked to embryonic stem cells.
    The 2007 document highlights the discovery that hair follicle bulge area contains pluripotent adult stem cells expressing nestin and CD34, which can differentiate into various cell types such as neurons, glia, and smooth muscle cells. These stem cells have been successfully used in vivo to promote nerve regeneration and functional recovery in mice with severed sciatic or tibial nerves, by differentiating primarily into Schwann cells. The findings suggest that hair follicle stem cells could serve as a valuable source for autologous stem cell therapy for peripheral nerve injuries, offering a solution without the ethical concerns of embryonic stem cells. While the potential for hair restoration is mentioned, it is not the main focus of the document.
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