Lack of Significant Association Between Sex Hormone Concentrations and Atopic Dermatitis in Adolescents and Adults in Two Population-Based Studies

    July 2021 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Hanna Kische, Anke Hannemann, Catharina Voß, Matthias Nauck, Henry Völzke, Lars Pieper, Katja Beesdo‐Baum, Andreas Arnold
    TLDR Sex hormones likely don't affect atopic dermatitis in adolescents and adults.
    The research examined the relationship between sex hormones and atopic dermatitis (AD) in two population-based studies, the Behavior and Mind Health Study (BeMIND) with 979 participants, and the Study of Health in Pomerania (SHIP-TREND) with 992 participants. The results showed no significant association between sex hormones and AD in both sexes, contradicting previous hypotheses that androgens and estrogens are linked with AD. The study suggests that the influence of sex hormones on AD might be regulated by receptors, sensitivity, and intraindividual changes of sex hormone concentrations. Despite the large sample size, the study had limitations such as regional samples and lack of information on polycystic ovarian syndrome and exact menstrual cycle timing. Future research focusing on specific subgroups like those in puberty, pregnancy, and menopausal transition is recommended.
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