A Different Approach to PCOS: Evaluation of Spermiogram Results in Male Patients With a Family History of PCOS

May 2025 in “ Gynecological Endocrinology ”

Müjde Can İbanoğlu, A. Yildiz, Ozde Beren Tatar, Berna Seçkin, Tufan Çiçek, Yaprak Engin Üstün

PCOS polycystic ovary syndrome spermiogram hair loss gynecomastia dyslipidemia sperm concentration sperm motility

TLDR Men with a family history of PCOS have lower sperm concentration and more hair loss.

This study investigated the impact of a family history of polycystic ovary syndrome (PCOS) on male reproductive health by analyzing spermiogram parameters in 51 men, 25 with a first-degree relative with PCOS and 26 without. Men with a family history of PCOS had significantly lower median sperm concentration (0.6 million/ml) compared to the control group (11.1 million/ml). Additionally, 64% of these men experienced hair loss, and 25% had gynecomastia. The study suggests a genetic influence on male reproductive health, with hormonal and metabolic changes similar to those seen in women with PCOS. It emphasizes the need for individualized approaches and lifestyle changes to improve reproductive health in this group.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Transgenerational Transmission of Reproductive and Metabolic Dysfunction in Male Progeny of Polycystic Ovary Syndrome

1 citations , May 2023 in “Cell reports medicine”

Sons of mothers with polycystic ovary syndrome (PCOS) have a higher risk of obesity and insulin resistance, possibly due to certain genes and factors passed down from their mothers.

research A Study on the Relationship Between Androgenetic Alopecia and Cardiovascular Risk Using High Sensitivity C-Reactive Protein and Galectin-3 in Men With Early Onset Baldness

December 2021 in “Biomarkers”

Men with early baldness have similar heart risk factors as others, but certain proteins are linked to higher heart disease risk.

research Obesity and Polycystic Ovary Syndrome

90 citations , January 2021 in “Clinical Endocrinology”

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

research In Search of New Therapeutics: Molecular Aspects of the PCOS Pathophysiology - Genetics, Hormones, Metabolism and Beyond

44 citations , September 2020 in “International Journal of Molecular Sciences”

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

research A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women

47 citations , June 2016 in “JAMA Dermatology”

Men with early hair loss have similar hormone levels to women with PCOS, possibly increasing risk of obesity and heart issues.

research Assessment of Semen Quality in Patients with Androgenetic Alopecia in an Infertility Clinic

August 2015 in “Dermatologica Sinica”

Men with severe hair loss may have poorer sperm quality.