Preparation and hemostatic mechanism of bioactive glass-based membrane-like structure camouflage composite particles

This study focused on the development of bioactive glass-based membrane-like structure camouflage composite particles ([email protected]/CS) using a Layer-by-layer method to enhance wound hemostasis. The particles were designed to coat bovine serum albumin and chitosan on macroporous and mesoporous bioactive glass, significantly improving coagulation by activating both endogenous and exogenous pathways. The [email protected]/CS particles demonstrated excellent water absorption and immediate Ca2+ release, forming a fibrin network that aggregated erythrocytes and activated platelets. In experiments with SD rats, these particles effectively reduced bleeding time and blood loss in both surface and internal bleeding models, suggesting their potential as a hemostatic biomaterial for emergency bleeding situations.