Rejuvenation by Design: Building Cosmetic Products with Extracellular Vesicle Technology, the Example of Exo.Reset

The chapter provides a comprehensive case study on the development of Exo.Reset®, a cosmetic product designed for skin rejuvenation using extracellular vesicle (EV) technology. It highlights the application of international Good Practices and guidelines, such as MISEV2013 and South Korea's 2024 guidelines, to ensure scientific rigor and regulatory compliance. The research and development process includes EV isolation, purification, characterization, and in vitro assessments with human dermal fibroblast cultures, focusing on gene expression changes related to skin rejuvenation. The study emphasizes quality control, reproducibility, and ethical considerations, offering a model for integrating EV technology into cosmetics and advancing skin care innovations.