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Did you mean Cardiotoxicity?

GlossaryCardiotoxicity

damage to heart muscle from certain drugs or toxins

Cardiotoxicity refers to the damage that certain substances, such as chemotherapy drugs or toxins, can cause to the heart muscle. This damage can lead to a range of heart problems, including arrhythmias (irregular heartbeats), heart failure, and reduced heart function. For professionals, monitoring for cardiotoxicity is crucial when administering treatments known to have potential cardiac side effects, as early detection can help mitigate long-term damage.

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Research

5 / 379 results

Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

research Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

1461 citations , March 2004 in “Annals of oncology”

Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.

Early Detection of Doxorubicin-Induced Cardiotoxicity in Minipigs Using Magnetic Resonance Imaging

research Détection précoce de la cardiotoxicité due à la doxorubicine chez le miniporc par imagerie par résonance magnétique

August 2016 in “PolyPublie (École Polytechnique de Montréal)”

Doxorubicin causes heart damage, so early detection and monitoring are important during chemotherapy.

research Cardiac morphologic alterations in acute minoxidil cardiotoxicity in miniature swine

27 citations , August 1984 in “Experimental and Molecular Pathology”

research The significance of the apelinergic system in doxorubicin-induced cardiotoxicity

13 citations , July 2024 in “Heart Failure Reviews”

The apelinergic system might protect the heart from damage caused by doxorubicin.

research Hypertrichosis due to minoxidil

45 citations , November 1979 in “British Journal of Dermatology”

Minoxidil causes excessive hair growth in almost all patients.

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community Why are there no proper phase 3 trials for RU

in Chat 4 upvotes 4 months ago

RU58841 lacks FDA approval due to financial and safety concerns, including potential cardiological side effects. The company abandoned further research, and users report adverse effects like heart palpitations and gynecomastia.

community P-1075: a BETTER version of Minoxidil

in Research/Science 10 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

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