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GlossaryCardiotoxicity

damage to heart muscle from certain drugs or toxins

Cardiotoxicity refers to the damage that certain substances, such as chemotherapy drugs or toxins, can cause to the heart muscle. This damage can lead to a range of heart problems, including arrhythmias (irregular heartbeats), heart failure, and reduced heart function. For professionals, monitoring for cardiotoxicity is crucial when administering treatments known to have potential cardiac side effects, as early detection can help mitigate long-term damage.

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Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

research Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

1461 citations , March 2004 in “Annals of oncology”

Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.

research Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats.

24 citations , February 2016 in “PubMed”

Royal jelly can protect the heart from damage caused by paclitaxel.

Early Detection of Doxorubicin-Induced Cardiotoxicity in Minipigs Using Magnetic Resonance Imaging

research Détection précoce de la cardiotoxicité due à la doxorubicine chez le miniporc par imagerie par résonance magnétique

August 2016 in “PolyPublie (École Polytechnique de Montréal)”

Doxorubicin causes heart damage, so early detection and monitoring are important during chemotherapy.

research Cardiac morphologic alterations in acute minoxidil cardiotoxicity in miniature swine

27 citations , August 1984 in “Experimental and Molecular Pathology”

research The significance of the apelinergic system in doxorubicin-induced cardiotoxicity

13 citations , July 2024 in “Heart Failure Reviews”

The apelinergic system might protect the heart from damage caused by doxorubicin.

research Hypertrichosis due to minoxidil

45 citations , November 1979 in “British Journal of Dermatology”

Minoxidil causes excessive hair growth in almost all patients.

research Cardiovascular toxicity of minoxidil in the marmoset

15 citations , August 2008 in “Toxicology Letters”

High doses of minoxidil can harm marmoset hearts and kidneys, possibly affecting humans similarly.

research INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Human serum albumin nanoparticles for enhanced drug delivery to treat breast cancer: Preparation and In Vitro assessment

2 citations , January 2012

HSA nanoparticles can improve tamoxifen delivery for breast cancer treatment, reducing side effects.

research Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway

January 2023 in “Discovery medicine”

Cepharanthine helps reduce cell aging caused by the cancer drug Doxorubicin by boosting cell cleanup processes.

research The role of 3Rs in the age of One Health: where we are and where we’re going

October 2023 in “Biomedical science and engineering”

Innovative methods are reducing animal testing and improving biomedical research.

research Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin

63 citations , February 2013 in “Human cell”

PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.

research Anthracycline analogs The past, present, and future

168 citations , December 1986 in “Cancer Chemotherapy and Pharmacology”

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

research Liposomes in cancer therapy

21 citations , May 1989 in “Advanced Drug Delivery Reviews”

Liposomes show promise in cancer treatment by delivering drugs with less toxicity and improved effectiveness.

research Streptomyces-derived nano-doxorubicin: Clinical status and patents granted

January 2024 in “Scripta Medica”

Nanoparticle delivery can reduce side effects of the cancer drug doxorubicin.

research The side effects of platinum-based chemotherapy drugs: a review for chemists

1108 citations , January 2018 in “Dalton transactions”

Platinum-based chemotherapy drugs can cause many severe side effects, often requiring dose reductions and additional medications to manage.

research Cardiovascular Toxicities of Androgen Deprivation Therapy

45 citations , April 2021 in “Current Treatment Options in Oncology”

ADT for prostate cancer may harm the heart, but GnRH antagonists might be safer.

research Mitoxantrone

44 citations , August 1996 in “Drugs & Aging”

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

research Multiple sclerosis disease-modifying therapies: adverse effect surveillance and management

18 citations , March 2006 in “Expert Review of Neurotherapeutics”

The document concludes that managing side effects of MS therapies is crucial for treatment success and patient adherence.

research A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro

12 citations , September 2015 in “Drug Design Development and Therapy”

AD198 is more effective than doxorubicin in stopping certain dog cancer cells.

research Olive and olive oil: a one stop herbal solution for the prophylaxis and management of cardiovascular disorders

1 citations , January 2021 in “Elsevier eBooks”

Olive and olive oil help prevent and manage heart diseases.

Boron/Nitrogen-Doped Carbon Nano-Onions as Nanocarriers for Targeted Breast Cancer Therapy

research B/N-doped carbon nano-onions as nanocarriers for targeted breast cancer therapy

January 2025 in “Nanoscale”

Boron/nitrogen-doped carbon nano-onions improve targeted breast cancer treatment by enhancing drug delivery and reducing side effects.

Cytostatics and Immunosuppressive Drugs: Toxicities and Management

research Cytostatics and immunosuppressive drugs

January 1989 in “Side effects of drugs annual”

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

Adverse Drug Reactions and Interactions: Case Studies

research Volume 1982, No. 4 February 26, 1982

January 1982 in “Clin-Alert”

Some medications caused temporary health issues that improved after stopping the drugs, but two patients died from liver problems linked to carbamazepine.

$Doxil (Caelyx): An Exploratory Study with Pharmacokinetics in Patients with Hormone-Refractory Prostate Cancer$

research Doxil (Caelyx): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer

81 citations , February 2000 in “Anti-cancer drugs”

Doxil showed some effectiveness against advanced prostate cancer but caused severe side effects at higher doses.

Age Dependence of the Cardiac Lesions Induced by Minoxidil in Rats

research Age dependence of the cardiac lesions induced by minoxidil in the rat

23 citations , June 1996 in “Toxicology”

Older rats more affected by minoxidil's cardiotoxic effects than younger rats.

Industry Report: Developments in Regenerative Medicine and Biotechnology Between July 1, 2009, and August 31, 2009

research Industry Report

November 2009 in “Regenerative Medicine”

The regenerative medicine industry saw business growth with new partnerships, clinical trials, and financial investments.

research Acute cardiomyopathy induced by the vasodilating antihypertensive agent minoxidil

52 citations , March 1979 in “Toxicology and Applied Pharmacology”

Minoxidil can cause heart muscle damage in dogs.

Early Cardiac Damage Following Single and Combined Exposure to Lithium Carbonate and Lead Acetate in Rats: A Toxicological Perspective

research EARLY CARDIAC DAMAGE FOLLOWING SINGLE AND COMBINED EXPOSURE TO LITHIUM CARBONATE AND LEAD ACETATE IN RATS: A TOXICOLOGICAL PERSPECTIVE

January 2025 in “Exploratory Animal and Medical Research”

Lithium carbonate and lead acetate together harm the heart more than individually.

research Chemotoxicity in Carcinoma Breast Patients - Its Incidence and Trends in Severity - An Observational Study

March 2021 in “Journal of Evolution of Medical and Dental Sciences”

Chemotherapy causes hair loss, nausea, fatigue, and blood issues, but counseling can help manage these effects.

research Adverse Dermatologic Effects of Cardiovascular Drug Therapy: Part III

15 citations , November 2002 in “Cardiology in Review”

Cardiovascular drugs can cause various skin problems, so recognizing these reactions is important.