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GlossaryCD39

enzyme that regulates immune responses by breaking down ATP and ADP

CD39, also known as Ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1), is an enzyme found on the surface of certain cells, including immune cells. It plays a crucial role in regulating inflammation and immune responses by breaking down ATP and ADP, which are molecules that can signal danger or damage in the body. This helps to control the activity of immune cells and maintain tissue homeostasis.

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Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

research Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease

30 citations , July 2019 in “PloS one”

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

research Evaluation of CD4+, CD39+, FOXP3+Tregulatory cells in Iraqi Alopecia areata patients by ELISA

October 2022 in “Journal of pharmaceutical negative results”

People with Alopecia areata have higher levels of certain T regulatory cells in their blood.

research Tregs: Where We Are and What Comes Next?

130 citations , November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

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