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GlossaryBRAF inhibitors

drugs that block mutated BRAF protein to treat cancer

BRAF inhibitors are a class of drugs designed to block the activity of the BRAF protein, which is involved in sending signals inside cells and can contribute to cancer growth when mutated. These inhibitors are particularly used in treating certain types of melanoma and other cancers with specific BRAF mutations, helping to slow down or stop the progression of the disease.

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community Huge Group Buy is Now Live with New and Existing Treatments

in Product 146 upvotes 2 years ago

A group buy for hair loss treatments including Harmine 19a, TM5614, Abiraterone Acetate, and others. A compound, BMS-202, that can potentially reverse gray hair is also mentioned.

community 27M Struggling with 5-Month Treatment Limit on Minoxidil and Finasteride, Seeking AR Blocker Advice

in General 111 upvotes 9 months ago

A 27-year-old male is experiencing a recurring pattern of hair loss after 5 months of using oral minoxidil and finasteride, despite initial success. He is considering using topical androgen receptor blockers like RU58841, pyrilutamide, or clascoterone to address potential androgen receptor hypersensitivity.

community Fevipiprant 2019!

15 upvotes 9 years ago

The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

community Pirfenidone - The answer to fibrosis and baldness

in Treatment 19 upvotes 4 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

community Has anyone find a way to stop/limit ru58841 to go systematic ?

in Finasteride/Dutasteride 4 upvotes 1 year ago

RU58841 is a strong non-steroidal antiandrogen for hair loss but may cause cardiovascular issues in some users. Alternatives like Pyrilutamide and Breezula are suggested due to better safety profiles and lower systemic risks.

community ABS-201 Trial - What should I know going in

in Research/Science 28 upvotes 2 months ago

The conversation is about a user preparing to join the ABS-201 clinical trial for hair loss treatment, which involves a prolactin inhibitor. The user plans to update others on their progress if enrolled.

community Group Buy for MR antagonist finerenone

in Product 11 upvotes 3 years ago

User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

community Allergan recruiting for Setipiprant trial in the US

13 upvotes 9 years ago

The conversation discusses a clinical trial for Setipiprant in the US, starting June 29th, with eligibility excluding recent users of minoxidil or finasteride. It encourages informed decision-making before signing up.

community MY ANECDOTAL REPORT ON SAFETY OF ALFATRADIOL AND FLURIDIL COMBINED WITH FINASTERIDE! COMPOUNDS APPROVED FOR MPB IN THE EUROPEAN UNION (i cant comment on the efficacy, cause i am on other treatments)

in Treatment 9 upvotes 4 years ago

The safety of combining alfatradiol and fluridil with finasteride as a potential treatment for male pattern baldness, which is approved in the European Union. Other treatments such as minoxidil and RU58841 were also discussed.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 8 upvotes 11 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community Guys if you can’t take 5AR inhibitors still get on treatment ASAP

in Treatment 44 upvotes 5 months ago

Minoxidil, alfatradiol, nizoral, and pyrilutamide can maintain hair for those who can't tolerate finasteride. Consistent use of these treatments can help prevent further hair loss.

community Breezula phase 3 results said to be released next month

in Product 27 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community Breezula hasn't even begun phase 3 trials yet. F*cking hell.

in Treatment 44 upvotes 4 years ago

The conversation is about the delay in Breezula's phase 3 trials and skepticism regarding its effectiveness compared to other treatments like RU58841 and Pyrilutamide. Some users prefer safety over effectiveness, while others express frustration with the slow progress and doubt Breezula will be a significant treatment for hair loss.

community Upcoming Setipiprant clinical trials hint at systemic daily dosage

22 upvotes 10 years ago

The conversation discusses the safety, tolerability, and efficacy of oral Setipiprant tablets for treating androgenetic alopecia compared to finasteride. It mentions the high cost of Setipiprant on the black market and the trial's end date in September 2017.

community Thinking about signing up for the setipiprant clinical trials

4 upvotes 8 years ago

The conversation discusses hair loss treatments, with the original poster considering joining a clinical trial for setipiprant after experiencing side effects from finasteride and disinterest in minoxidil. Some users express skepticism about setipiprant's effectiveness, while others encourage participation in the trial for potential benefits.

community will long term 5ar inhibition alter my physical appearance?

in Treatment 2 upvotes 1 year ago

A 19-year-old concerned about long-term effects of 5AR inhibitors on physical appearance. They have used finasteride and plan to try dutasteride or RU58841; responses suggest improved skin, hair, and confidence.

community Pyrludimide (KX-826) or Breezula (clascoterone)

in Treatment 9 upvotes 2 months ago

The conversation is about hair loss treatments, specifically Pyrludimide (KX-826) and Breezula (clascoterone), with the user unable to tolerate finasteride and dutasteride. The user plans to use these treatments alongside minoxidil, considering the efficacy and availability of each option.

community Setipiprant trial results

in Update 10 upvotes 7 years ago

Setipiprant trial for hair loss failed, showing no difference between placebo and treatment. Discussion also noted placebo users reporting side effects.

community pyrilutamide solution progress log

in Product 20 upvotes 3 years ago

A 28 year old using a hair loss prevention protocol to restore thinning hair, which includes finasteride, dutasteride, minoxidil, stemoxydine, alopecin, nizoral shampoo and microneedling; the user is now adding pyrilutamide solution to the regimen with the hope of improving their results. RU58841 was also ordered but not yet used.

community Dose of oral spironolactone for males to stop hairloss when 5ari blockers not working, any idea

in Treatment 6 upvotes 2 months ago

The conversation discusses using oral spironolactone for hair loss in males when 5ari blockers fail. Concerns are raised about spironolactone's side effects, and alternatives like pyrilutamide and breezula are suggested.

community Breezula Phase 3 Results enough for maintenance?

in Treatment 11 upvotes 1 month ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

community Doctors won't let me try bicalutamide or fin

in Female 6 upvotes 5 years ago

Hair loss treatments discussed include 200mg Spiro, bicalutamide, and finasteride. Endocrinologist advises against bicalutamide and finasteride due to potency and risks.

community Are there any men here who have taken bicalutamide without estradiol?

in Progress Pictures 4 upvotes 3 years ago

Men discussing hair loss treatments, including bicalutamide, cyproterone acetate, dutasteride, minoxidil, and RU58841. They share experiences and concerns about side effects like infertility, liver health, and feminization.

community Are these all the anti androgen products?

in Treatment 6 upvotes 2 years ago

The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

community Pyrilutamide with Alfatradiol and minoxidil (23M)

in Treatment 2 upvotes 6 months ago

The user experienced side effects from a hair loss treatment and is considering using pyrilutamide, alfatradiol, and possibly minoxidil. They are unsure about starting minoxidil immediately or waiting to see the effects of the other treatments.

community Breezula Phase 3 confusion - did they change something?

in Chat 10 upvotes 4 months ago

Breezula's phase 2 showed reduced efficacy after 6 months, but phase 3 had positive results, causing confusion about any changes made to the drug. There is frustration over the long timeline for hair loss treatments, with some users expressing more interest in other potential treatments like GT-20029.

community Why is the general consensus that if you can’t tolerate 5AR Inhibitors you’re “cooked”?

in Research/Science 15 upvotes 7 months ago

Alternatives to finasteride for hair loss include minoxidil, alfatrodial, fluridil, pyrilutamide, and Nizoral. These treatments may not be as effective as finasteride but can help slow hair loss progression.

community Sensitive to Oral fin + RU. Am I screwed?

in Product 5 upvotes 4 years ago

Akinfenrawr experienced negative side effects from oral finasteride and RU58841, and is seeking alternative hair loss treatments. They discuss various options, including raloxifene, oral dutasteride, liposomal finasteride, Breezula, Pyrilutamide, SM04554, and sulforaphane, but have concerns about efficacy, availability, and cost.

community What happens if you combine dutasteride and a aromataze inhibitor?

in Question 4 upvotes 7 years ago

Combining dutasteride and an aromatase inhibitor may increase testosterone levels significantly, potentially enhancing athletic performance but also posing health risks like elevated blood pressure and worsened cholesterol. The user is experimenting with dutasteride, anastrozole, minoxidil, and ketoconazole shampoo to manage hair loss and estradiol levels, while monitoring side effects and hormone levels.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 2 years ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.