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    Did you mean Cornified Envelope?
    GlossaryCornified Envelope

    tough, protective layer in the outermost skin part

    The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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      community Hair loss research is a money grab

      in Chat  225 upvotes 5 months ago
      Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

      community Dutasteride Users, do you Still Take Creatine?

      in Finasteride/Dutasteride  12 upvotes 9 months ago
      The conversation discusses the potential impact of creatine on hair loss, with some users sharing personal experiences of increased shedding while others argue there's no scientific evidence linking creatine to hair loss. The original poster switched from finasteride to dutasteride and is considering resuming creatine after monitoring its effects on hair loss.

      community 3 months progress with Finasteride 0.5mg/daily, Minoxidil foam5% 2x daily, Stemoxydine 2x daily, Microneedling(M8) 1.5mm 1x per week, Saw Palmetto 400mg/day, peppermint and jojoba oils daily, Ketoconazole 2% shampoo 3x/week, Purador shampoo/conditioner every day.

      in Progress Pictures  341 upvotes 3 years ago
      Jordan-Iliad has been using a combination of finasteride, minoxidil, stemoxydine, microneedling, saw palmetto, peppermint and jojoba oils, ketoconazole shampoo, and Purador shampoo/conditioner for 3 months to treat their hair loss with stunning results. They have also recently started taking oral minoxidil 1.25mg/day in hopes of achieving even better results over the next 3 months.

      community Certified old, at 51, balding since 25, the resurrection!

      in Progress Pictures  439 upvotes 1 year ago
      A 51-year-old shared progress on hair regrowth using topical Minoxidil and Finasteride over four months, noting significant improvement and plans for future hair transplants. The user emphasized the benefits of modern treatments and societal changes in attitudes towards hair loss.

      community I just went to a dermatologist and there were many red flags about him.

      in Treatment  13 upvotes 3 years ago
      A user visited a dermatologist for hair loss concerns and was prescribed a hair lotion called "Lotion revolotion evdermia," which is meant for hair toning, hydration, and anti-aging, not regrowth. The user found the dermatologist's behavior and the prescription to be questionable.

      community What Are the Technicalities of Curved Hair Transplantation?

      in Transplants  4 upvotes 3 weeks ago
      Curved hair transplantation requires specialized tools and techniques to avoid damaging hair follicles, with modified FUE being the preferred method. Proper extraction and implantation angles are crucial to prevent complications like keloids and sterile folliculitis.

      community Went to the derm..

       15 upvotes 10 years ago
      Finasteride is recommended for hair loss treatment, with potential side effects like erectile issues in 1 in 33 users, which typically resolve after stopping the drug. Users report mixed experiences, with some experiencing initial side effects like brain fog and others seeing no issues, and the drug is generally considered effective for maintaining or regrowing hair.

      community Oral Min & Fin - 9 Months no results - diffuse thinner

      in Treatment  6 upvotes 1 year ago
      A 21-year-old has been using 0.4mg finasteride and 1mg oral minoxidil (increased to 2mg) for 9 months with no noticeable hair growth and worsening hair condition. They are considering stopping finasteride due to side effects and are seeking advice on other treatments.

      community I just want to say Ru58841 saved my life.

      in Chat  28 upvotes 3 years ago
      A user's experience with hair loss and scalp inflammation, which was alleviated by using RU58841 along with finasteride and dutasteride. A theory of inflammation possibly being a cause of hairloss is also discussed.

      community Topical tretinoin increases minoxidil absorption by 3x. Thoughts?

      in Minoxidil  37 upvotes 7 years ago
      Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

      community Kiierr 312 MD DualWave Laser Review

      in Technology  1 upvotes 1 week ago
      The user reviewed the Kiierr 312 MD DualWave Laser for hair loss, using it alongside ketoconazole shampoo, Svvimer products, and oral finasteride. They also mentioned using minoxidil on their face and adjusting lifestyle factors like sleep, vitamin D, and protein intake.

      community Is sustained Finasteride use safe?

      in Finasteride/Dutasteride  4 upvotes 1 month ago
      A 28-year-old experienced hair loss and found success with daily 1mg Finasteride, noticing thicker hair without side effects. Despite this, their dermatologist suggested switching to expensive peptide serums, prompting the individual to seek a second opinion on long-term Finasteride and oral Minoxidil use.

      community 1 year progression dut+minox...

      in Progress Pictures  592 upvotes 6 months ago
      The conversation is about a user's one-year hair loss treatment using dutasteride, oral and topical minoxidil, ketoconazole, tretinoin, and PRP. Users discuss treatment effectiveness, potential issues with diffuse thinning, and sourcing affordable treatments.

      community Topical solution recommendation

      in Treatment  2 upvotes 8 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 8 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Hair loss 30F - thoughts on red light therapy vs min/fin?

      in Female  6 upvotes 1 year ago
      The conversation discusses hair loss treatments for a 30-year-old female, comparing red light therapy with minoxidil and finasteride. Concerns about hormonal impact and potential pregnancy are raised, with suggestions to consider spironolactone and microneedling, while emphasizing the importance of consulting a dermatologist.

      community PSA: Caffeine and Hair Transplants

      in Transplants  28 upvotes 1 year ago
      A user shared their experience with a hair transplant, emphasizing the importance of avoiding caffeine 7 days before the procedure. Ignoring this advice led to reduced effectiveness of the numbing agent, causing significant discomfort during the transplant.

      community Nearly 3 years in and I'm on a mega growth spurt. Don't lose heart.

      in Chat  63 upvotes 1 year ago
      The user experienced subtle hair growth improvements using finasteride, dutasteride, and minoxidil over nearly three years, with notable progress at the temples. The front hairline shows quicker regrowth cycles, but the vertex and crown remain unchanged.

      community Tretinoin can make it worse!!!

      in Chat  7 upvotes 2 years ago
      Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.