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    GlossaryFAIRE-seq

    technique to identify active regulatory regions in the genome

    FAIRE-seq, or Formaldehyde-Assisted Isolation of Regulatory Elements sequencing, is a technique used to identify regions of the genome that are active in regulating gene expression. It works by using formaldehyde to crosslink DNA and proteins, then isolating the DNA that is not tightly bound to proteins, which typically corresponds to regulatory elements like enhancers and promoters. This isolated DNA is then sequenced to map these regulatory regions across the genome.

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      community Average tressless user after taking oral minoxidil

      in Satire  1439 upvotes 3 years ago
      The conversation is about hair loss and the use of minoxidil (Minoxidil) and finasteride (Fin) as treatments. The conclusion is that some users have seen success in maintaining their hair with minoxidil, but there are varying opinions on the effectiveness of the treatments.

      community I have a question for everyone about the new UCLA research

      in Chat  11 upvotes 1 year ago
      The conversation discusses skepticism about a new hair loss treatment called project K, which claims to replicate a chemical from UCLA research but is suspected to be a scam. The original poster plans to continue using oral minoxidil, finasteride, and dutasteride, along with microneedling, for hair regrowth.

      community I have started taking creatine supplement

      in Product  17 upvotes 2 years ago
      The conversation discusses the potential impact of creatine on hair loss, with some users reporting no effect and others experiencing increased hair shedding. The original poster is using finasteride, minoxidil, and a derma pen, and has started taking creatine to observe any changes in hair loss.

      community How likely do you think it is for PP405 to come out?

      in Research/Science  21 upvotes 8 months ago
      PP405 is a potential new hair loss treatment that works through metabolic pathways rather than hormonal ones, with an estimated market release between late 2027 and 2029. Current alternatives to finasteride include minoxidil, pyralutamide, fluridil, and RU58841, with hair transplants also being a viable option.

      community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

      in Technology  613 upvotes 1 month ago
      A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

      community Success Story - In Case I Can Help Others

      in Treatment  12 upvotes 4 months ago
      A user shared their experience with hair loss, initially using oral finasteride and minoxidil but experiencing side effects like low libido and ED. They switched to a topical finasteride and minoxidil combination, which improved their hair thickness with fewer side effects.

      community Journey against alopecia - Finasteride 3 month

      in Progress Pictures  18 upvotes 4 years ago
      A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.

      community My hair journey: 2017 through the present

      in Progress Pictures  511 upvotes 1 year ago
      A user shared their hair loss journey from 2017 to 2024, detailing the use of finasteride, minoxidil, dutasteride, supplements, and dermarolling. They experienced significant hair loss after stopping finasteride in 2017, saw some regrowth after resuming treatments in 2023, and are considering a hair transplant.

      community If RU58841 is such an effective anti androgen

      in Research/Science  46 upvotes 2 years ago
      RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

      community Are there ever going to be any oral DHT blocking treatments in the future?

      in Product  4 upvotes 2 years ago
      The discussion revolves around the need for future oral DHT blockers for hair loss treatment that don't have the side effects of current options like Finasteride and Dutasteride. One user suggests that the future of hair loss treatment will likely be topical anti-androgens, as they can target hair follicles without affecting the entire system.

      community How do we only have two treatments to combat hair loss at this point in time?

      in Chat  211 upvotes 3 years ago
      The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

      community It's not fair I'm the one who's supposed to have the most hair.

      in Satire  78 upvotes 10 months ago
      People discussed hair loss treatments, including finasteride, minoxidil, and microneedling, with varying results and concerns about genetics and hormone levels. Some users shared personal experiences with medication dosages and side effects, while others mentioned the impact of stress on hair loss.

      community To be fair...

      in Satire  4 upvotes 8 years ago
      The conversation humorously discusses the complexity of understanding and treating male pattern hair loss, mentioning treatments like Minoxidil, finasteride, RU58841, Dr. Brotzu's lotion, and Dr. Tsuji's hair cloning. The original post satirically claims that only those with high intelligence can appreciate these treatments.

      community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

      in Female  42 upvotes 5 years ago
      User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

      community Kintor money grab, unacceptable

      in Product  76 upvotes 1 year ago
      Kintor's KX826 (pyrilutamide) is ineffective at 0.5% and overpriced at 1%, leading to user frustration and calls for fair pricing. Users suggest sticking with proven treatments like Minoxidil and Finasteride.

      community Year and a half finasteride only

      in Progress Pictures  293 upvotes 2 years ago
      A user shared their positive experience with thicker hair and improved confidence after a year and a half of using finasteride without side effects. Specific treatments discussed include oral finasteride, with a question about the daily dosage.

      community 3 month progress on Minoxidil 5% only.

      in Is this regrowth?  1037 upvotes 2 years ago
      A user is pleased with their hair regrowth after 3 months using Minoxidil 5%. They plan to start Finasteride upon returning home, and others discuss the importance of consistency and patience with hair loss treatments.

      community Who's tried these topical solutions?

      in Treatment  10 upvotes 2 years ago
      Topical melatonin, caffeine, and adenosine have shown impressive results in increasing hair density by 55% in 8 weeks, according to a Medium article.
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