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GlossaryHair Cycle Clock

internal mechanism regulating hair growth, rest, and shedding phases

The Hair Cycle Clock refers to the internal biological mechanism that regulates the phases of hair growth, rest, and shedding. This cycle includes the anagen (growth), catagen (transitional), and telogen (resting) phases, ensuring that hair follicles undergo a synchronized process of renewal and shedding. Understanding this clock is crucial for diagnosing and treating hair disorders like alopecia.

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research Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

116 citations , May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

research A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

92 citations , September 2013 in “Journal of Investigative Dermatology”

BMAL1 and Period1 genes can influence human hair growth.

Hunting the Hair Cycle Clock: Evidence That Mitochondrially Localized MPZL3 Is a Key Element in Murine and Human Hair Follicles

research 715 Hunting the hair cycle clock (HCC): Evidence that mitochondrially localized MPZL3 is a key HCC element in murine and human hair follicles

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 is important for controlling the hair growth cycle in mice and humans.

research 583 Hair cycle regulation by a mitochondrially localized protein: Is MPZL3 a central component of the elusive hair cycle clock?

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 protein is important for controlling hair growth cycles.

research New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

68 citations , April 2012 in “Journal of Investigative Dermatology”

The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.

research Overview of the Circadian Clock in the Hair Follicle Cycle

July 2023 in “Biomolecules”

The circadian clock plays a key role in hair growth and its disruption can affect hair regeneration.

research Principles of Hair Cycle Control

109 citations , December 1998 in “The Journal of Dermatology”

Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.

research Clock genes, hair growth and aging

55 citations , March 2010 in “Aging”

Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.

research Hair Follicles as a Critical Model for Monitoring the Circadian Clock

5 citations , January 2023 in “International Journal of Molecular Sciences”

Hair follicles could be used to noninvasively monitor our body's internal clock and help identify risks for related diseases.

research Bioorthogonal Click-Engineered Microneedle Patch Enables Adeno-Associated Virus-Mediated Dermal Acidic Fibroblast Growth Factor Expression for Hair Loss Treatment

March 2026 in “ACS Nano”

A new microneedle patch effectively treats hair loss by delivering growth factors to the skin.

research Identification of lncRNAs involved in the hair follicle cycle transition of cashmere goats in response to photoperiod change

1 citations , May 2025 in “BMC Genomics”

lncRNAs may help control cashmere goat hair growth by responding to light changes.

research The Circadian Clock in Skin

127 citations , January 2015 in “Journal of Biological Rhythms”

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

research Hair follicles and their role in skin health

16 citations , December 2006 in “Expert Review of Dermatology”

Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.

research Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche

1 citations , August 2023 in “Nature communications”

Hdac1 and Hdac2 help maintain and protect the cells that control hair growth.

research Stem cells and the circadian clock

75 citations , September 2017 in “Developmental biology”

The circadian clock influences the behavior and regeneration of stem cells in the body.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells

22 citations , June 2017 in “Stem cell reports”

PTEN helps control the number and health of skin stem cells by working with the protein BMAL1.

Estimation Methods for Human Circadian Phase Using Peripheral Tissues

research Estimation methods for human circadian phase by use of peripheral tissues

14 citations , June 2016 in “Hypertension research”

New method uses hair follicle cells to estimate human body clock phase, potentially improving sleep disorder diagnosis.

research Transcriptomic regulation of seasonal coat color change in hares

18 citations , January 2020 in “Ecology and evolution”

Genes related to pigmentation, body rhythms, and behavior change during hares' seasonal coat color transition, with a common genetic mechanism in two hare species.

The Clock Within: Molecular Clock in Epidermis Regulates Circadian Rhythms and Stem Cell Cycles

research The clock within

6 citations , December 2011 in “Nature”

The circadian clock in skin cells controls their growth and rest cycles.

research Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition

April 2024 in “Communications biology”

Enzymes involved in Vitamin A metabolism affect hair growth and type in mice.

research Differential Expression of Proteins Associated with the Hair Follicle Cycle - Proteomics and Bioinformatics Analyses

10 citations , January 2016 in “PLOS ONE”

Researchers found 44 proteins that change during different hair growth stages and may be important for hair follicle function.

research Investigation of a non-invasive method of assessing the equine circadian clock using hair follicle cells

15 citations , October 2012 in “Journal of circadian rhythms”

RNA from horse hair follicles can track circadian rhythms non-invasively.