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GlossaryHypopigmentation

reduced melanin causes lighter skin patches

Hypopigmentation refers to a condition where patches of skin become lighter than the surrounding area due to a reduction in melanin, the pigment responsible for skin color. This can result from various causes, including skin injuries, certain medical conditions like vitiligo, or inflammatory skin disorders.

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research Tyrosinase Inhibition Due to Interaction of Homocysteine with Copper: Mechanism for Reversible Hypopigmentation in Homocystinuria Due to Cystathionine Beta-Synthase Deficiency

74 citations , July 1995 in “PubMed”

Lowering homocyst(e)ine levels can reverse skin and hair lightening by restoring enzyme activity needed for pigmentation.

research Hypopigmentation in Frontal Fibrosing Alopecia

23 citations , May 2017 in “Journal of the American Academy of Dermatology”

FFA patients have fewer melanocytes and thinner skin compared to others.

research Pluripotent Stem Cell Technology: A Promising Remedy for Hypopigmentation Disorders

1 citations , May 2017 in “Journal of Stem Cell Research & Therapeutics”

Pluripotent stem cells show promise for treating skin color loss disorders like vitiligo.

research Successful Treatment of Laser-Induced Hypopigmentation With Platelet-Rich Plasma: Case Report

November 2025 in “International Journal of Advanced Research”

Platelet-rich plasma therapy effectively treated laser-induced skin lightening.

research Oral Zinc Sulphate Causes Murine Hair Hypopigmentation And Is A Potent Inhibitor Of Eumelanogenesis In Vivo

30 citations , June 2006 in “British journal of dermatology/British journal of dermatology, Supplement”

Oral zinc sulphate reduces dark hair color in mice.

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community Can tretinoin cause problems or issues with min?

in Minoxidil 2 upvotes 10 months ago

The user is using a topical routine of finasteride and minoxidil, noticing increased hair growth, and is considering adding tretinoin for skin issues. Tretinoin may enhance minoxidil's effectiveness, but care should be taken to allow proper absorption to avoid unintended facial hair growth.

community Massive preliminary success with my thorough regime

in Update 4 upvotes 5 years ago

A 28-year-old male reported significant hair regrowth after 5 weeks using a regime including Minoxidil, Ketozolin shampoo, microneedling, hyaluronic acid, saw palmetto, pumpkin seed, MSM, frankincense, zinc, multivitamins, and vitamin D. He also noted improvements in digestion, dry eyes, and skin health, and observed beard growth from microneedling.

community 1 year progress 1mg oral Finasteride, 5% topical Minoxidil. 36M

in Is this regrowth? 153 upvotes 1 day ago

community microneedling and sun exposure

in Microneedling 10 upvotes 1 month ago

Avoid sun exposure for 7-14 days after microneedling the scalp, using a hat for protection. Sunscreen on the scalp can be messy and irritating.

community Tretinoin vs. micro-needling: what increases sulfotransferase activity more?

in Research/Science 1 upvotes 7 months ago

Tretinoin and microneedling both enhance hair growth through different mechanisms, with microneedling being considered safe for long-term use. Optimal microneedling needle length varies, but 0.8 mm is suggested for hair growth, and a Dermastamp is recommended to avoid skin damage.

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