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GlossaryPseudohermaphroditism

condition where genetic sex differs from external genitalia

Pseudohermaphroditism, also known as false hermaphroditism, is a condition where an individual has the genetic and gonadal sex of one gender (either male or female) but has external genitalia that resemble the opposite sex. For example, a person with male pseudohermaphroditism has XY chromosomes and testes but may have external genitalia that appear female. This condition can result from various genetic, hormonal, or developmental factors.

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research Male pseudohermaphroditism due to 17β-hydroxysteroid dehydrogenase deficiency: Studies on the natural history of the defect and effect of androgens on gender role

98 citations , July 1983 in “Journal of Steroid Biochemistry”

Individuals with this condition often develop male traits and identities at puberty despite being raised as females.

research Steroid 17β-hydroxysteroid dehydrogenase deficiency in man: An inherited form of male pseudohermaphroditism

46 citations , December 1992 in “The Journal of Steroid Biochemistry and Molecular Biology”

Affected males are born with ambiguous genitalia, raised as females, but develop male traits at puberty due to enzyme deficiency.

research Management of neonates and children with male pseudohermaphroditism

21 citations , December 1977 in “Journal of pediatric surgery”

Individuals with male pseudohermaphroditism often do better raised as females with early surgery.

research 5α-Metabolism in Finasteride-Treated Subjects and Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

8 citations , January 1991 in “European Urology”

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

research MALE PSEUDOHERMAPHRODITISM DUE TO 17β-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: STUDIES ON THE NATURAL HISTORY OF THE DEFECT AND EFFECT OF ANDROGENS ON GENDER ROLE

January 1983 in “Elsevier eBooks”

Masculinization in affected individuals occurs gradually after puberty due to hormone changes.

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community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 53 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community What is the cause of "DHT itch"?

in Research/Science 7 upvotes 1 year ago

The conversation discusses the effects of using Tongkat ali and dioscorea to raise DHT levels, leading to increased body hair growth and an itchy scalp, without causing hair loss. The discussion also debates the role of DHT in male characteristics and its impact on sexual function, with differing opinions on its importance and effects.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 2 years ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Been on Finasteride for 20 years. Recently started noticing some thinning near my temples. Unsure what to do next

in General 209 upvotes 8 months ago

A person has been using 1mg Finasteride for 20 years with no side effects but is now noticing temple thinning and is considering oral Minoxidil, despite concerns about heart health and body hair growth. They are consulting a doctor about possibly taking 1.25 to 2.5 mg of oral Minoxidil.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

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