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Did you mean Pseudohermaphroditism?

GlossaryPseudohermaphroditism

condition where genetic sex differs from external genitalia

Pseudohermaphroditism, also known as false hermaphroditism, is a condition where an individual has the genetic and gonadal sex of one gender (either male or female) but has external genitalia that resemble the opposite sex. For example, a person with male pseudohermaphroditism has XY chromosomes and testes but may have external genitalia that appear female. This condition can result from various genetic, hormonal, or developmental factors.

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research Male pseudohermaphroditism due to 17β-hydroxysteroid dehydrogenase deficiency: Studies on the natural history of the defect and effect of androgens on gender role

98 citations , July 1983 in “Journal of Steroid Biochemistry”

Individuals with this condition often develop male traits and identities at puberty despite being raised as females.

research Steroid 17β-hydroxysteroid dehydrogenase deficiency in man: An inherited form of male pseudohermaphroditism

46 citations , December 1992 in “The Journal of Steroid Biochemistry and Molecular Biology”

Affected males are born with ambiguous genitalia, raised as females, but develop male traits at puberty due to enzyme deficiency.

research Management of neonates and children with male pseudohermaphroditism

21 citations , December 1977 in “Journal of pediatric surgery”

Individuals with male pseudohermaphroditism often do better raised as females with early surgery.

research 5α-Metabolism in Finasteride-Treated Subjects and Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

8 citations , January 1991 in “European Urology”

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

research MALE PSEUDOHERMAPHRODITISM DUE TO 17β-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: STUDIES ON THE NATURAL HISTORY OF THE DEFECT AND EFFECT OF ANDROGENS ON GENDER ROLE

January 1983 in “Elsevier eBooks”

Masculinization in affected individuals occurs gradually after puberty due to hormone changes.

C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

research C₁₉and C₂₁5β/5αMetabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency*

55 citations , March 1990 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

research Clinical, Hormonal, Behavioral, and Genetic Characteristics of Androgen Insensitivity Syndrome in a Brazilian Cohort: Five Novel Mutations in the Androgen Receptor Gene

174 citations , July 2003 in “The Journal of Clinical Endocrinology & Metabolism”

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

research Structure of human type II 5 alpha-reductase gene.

124 citations , September 1992 in “Endocrinology”

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

research 5 alpha-reductase-2 gene mutations in the Dominican Republic.

53 citations , May 1996 in “The Journal of Clinical Endocrinology & Metabolism”

Different mutations in the 5 alpha-reductase-2 gene were found in affected individuals in the Dominican Republic, suggesting no common ancestry.

research THE FIBROBLAST AS A MODEL FOR ANDROGEN RESISTANT STATES

29 citations , May 1988 in “Clinical Endocrinology”

Fibroblasts help understand androgen resistance at the cellular level.

research Identification of a Rare Variant in the SRD5A2 Gene in Siblings With 46,XY Disorders of Sexual Development

January 2025 in “Case Reports in Genetics”

A rare gene variant causes sexual development issues in siblings, needing personalized treatment.

research Androgen Biosynthesis and Gene Defects

November 2014 in “Elsevier eBooks”

Gene mutations can cause problems in male genital development.

research 5alpha-reductase: history and clinical importance.

62 citations , January 2004 in “PubMed”

5alpha-reductase inhibitors like finasteride and dutasteride effectively treat BPH by reducing DHT, offering symptom relief and potential future uses.

research Markers of peripheral androgen action in vivo and in vitro

4 citations , October 1988 in “Clinics in Dermatology”

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

research Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates

21 citations , January 2020 in “General and Comparative Endocrinology”

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

research Mister XX

1 citations , January 2016 in “Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma”

Most 46XX CAH patients have female identity, but a few identify as male and may need treatment and surgery.

research Structure of human type II 5 alpha-reductase gene

76 citations , September 1992 in “Endocrinology”

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

research Preparation of3H-labelled testosterone metabolites

2 citations , April 2007 in “Journal of Labelled Compounds and Radiopharmaceuticals”

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

research Evolution, classification, structure, and functional diversification of steroid 5α-reductase family in eukaryotes

6 citations , July 2024 in “Heliyon”

Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.

research Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene

94 citations , April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research Male pattern hair loss: prevention rather than regrowth

6 citations , October 2000 in “International Journal of Dermatology”

Preventing hair loss is more effective than regrowth; oral finasteride is a realistic option.

research Evaluation and treatment of male and female pattern hair loss

203 citations , December 2004 in “Journal of The American Academy of Dermatology”

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers*

147 citations , April 1990 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride safely lowers DHT levels without affecting testosterone.

Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

research Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: A randomized, double-blind, placebo-controlled, phase III study

92 citations , June 2010 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg daily improves hair growth safely in men with hair loss.