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In Patients With Acne Vulgaris, How Do Standard Acne Treatments Combined With Adjunct Microbiome-Targeted Therapies Compare to Standard Acne Treatments Alone in Affecting Clinical Outcomes?

research In Patients With Acne Vulgaris, How Do Standard Acne Treatments Combined With Adjunct Microbiome-Targeted Therapies Compare to Standard Acne Treatments Alone in Affecting Clinical Outcomes?

May 2026 in “Rowan Digitals Works (Rowan University)”

Adding oral probiotics to standard acne treatments improves results and reduces side effects.

research Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

78 citations , June 2021 in “Dermatology and Therapy”

Future acne treatments should aggressively target inflammation to prevent scarring.

research Grand challenges in dermatologic drug discovery: four priorities to transform skin disease treatment

January 2026 in “Frontiers in Drug Discovery”

Transforming skin disease treatment requires new strategies, better drug models, and patient-focused research.

research Seborrheic Dermatitis Revisited: Pathophysiology, Diagnosis, and Emerging Therapies—A Narrative Review

3 citations , October 2025 in “Biomedicines”

New treatments for seborrheic dermatitis show promise for difficult cases.

Scalp Microbiome in Male Androgenetic Alopecia: 16S rRNA Sequencing-Based Clinical Characterization, Mouse Model Validation, and Effects on Hair Follicle Cells

research Scalp microbiome in male androgenetic alopecia: 16S rRNA sequencing-based clinical characterization, mouse model validation, and effects on hair follicle cells

July 2026 in “Frontiers in Cellular and Infection Microbiology”

Staphylococcus levels may indicate hair loss in men and could help develop new treatments.

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community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 93 upvotes 4 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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