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GlossaryAnagen Phase

active period of hair growth in the hair cycle

The Anagen Phase, also known as the growth phase, is the active period of hair growth in the hair cycle. During this phase, hair follicles are actively producing new hair cells, leading to the elongation of the hair shaft. This phase can last anywhere from 2 to 7 years, depending on genetic factors, and determines the maximum length of the hair.

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research A Comparison of Methods of Anagen Synchronization in the Adult Rat Model of Chemotherapy-Induced Alopecia

January 2015 in “Journal of clinical and investigative dermatology”

Clipping is the best method to prepare rats for studying hair loss from chemotherapy because it causes less skin damage and effectively gets hair to the right growth phase.

An Umbilical Cord Blood-Derived Exosome Product Stimulates Hair Growth Through Laminin V and Collagen XVII: An Ex Vivo Study

research A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study

November 2025 in “Archives of Dermatological Research”

Limelight (CB-EVs) safely promotes hair growth.

research [Effect of tacrolimus on the growth cycle of murine hair follicles].

1 citations , April 2007 in “PubMed”

Tacrolimus helps mice grow hair by activating hair follicles.

A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study

research A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

8 citations , October 2017 in “Dermatology practical & conceptual”

A spermidine-based supplement may help hair grow longer by keeping it in the growth phase.

Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

research Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

January 2025 in “MEDS Public Health and Preventive Medicine”

Spermidine supplements can help extend the hair growth phase and may be useful for treating hair loss.

research Hair-cycle dependent differential expression of ADAM 10 and ADAM 12

5 citations , January 2009 in “Dermato-endocrinology”

ADAM 10 and ADAM 12 proteins are involved in different stages of hair growth and could be targets for treating hair disorders.

Interest of Silybum Marianum Extract, Manganese PCA, and Lespedeza Capitata Extract in a New Anti-Hair Loss Serum to Stimulate Hair Growth and Prolong Anagen Phase

research 586 Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase

November 2022 in “Journal of Investigative Dermatology”

The extract of Silybum marianum, Manganese PCA, and Lespedeza capitata can boost hair growth and extend the growth phase when combined in a serum.

research ESDR586 - Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase

September 2022

The serum with these ingredients may help reduce hair loss and promote growth.

research Immunization by Application of DNA Vaccine onto a Skin Area Wherein the Hair Follicles Have Been Induced into Anagen-onset Stage

20 citations , August 2007 in “Molecular therapy”

Applying a DNA vaccine to skin with active hair growth boosts immune response and protection against anthrax in mice.

research Effect of Free Long-Chain Fatty Acids on Anagen Induction: Metabolic or Inflammatory Aspect?

March 2025 in “International Journal of Molecular Sciences”

Free long-chain fatty acids can stimulate hair growth in mice.

research [Proliferation behavior of the anagen hair bulb in androgenetic alopecia before and after local administration of 17 alpha- propylmesterolone–DNA flow cytophotometry studies].

December 1990 in “PubMed”

Topical 17 alpha-propylmesterolone increases hair cell growth in androgenetic alopecia.

research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle

41 citations , June 2010 in “Journal of Investigative Dermatology”

New cells are added to the hair's dermal papilla during the active growth phase.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

28 citations , October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

research Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells

15 citations , May 2020 in “BMC complementary medicine and therapies”

Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.

18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase

research 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase

July 2024 in “Biological and Pharmaceutical Bulletin”

Licorice extract helps hair growth and may treat hair loss.

research Identification of microRNAs in Wool Follicles during Anagen, Catagen, and Telogen Phases in Tibetan Sheep

37 citations , October 2013 in “PLoS ONE”

MicroRNAs play a key role in wool growth in Tibetan sheep.

Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5

7 citations , January 2019 in “Pharmaceutical Biology”

Eclipta prostrata helps hair growth and maintains the growth phase by affecting certain growth factors.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

6 citations , November 2013 in “International Journal of Radiation Biology”

Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.

CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

research CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

3 citations , April 2014 in “Journal of Dietary Supplements”

CARI ONE helps start hair growth and makes hair follicles bigger and more numerous.

research New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

68 citations , April 2012 in “Journal of Investigative Dermatology”

The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.

research Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation

29 citations , December 2016 in “The EMBO Journal”

Gata6 is important for protecting hair growth cells from DNA damage and keeping normal hair growth.

research LB1672 Senescent melanocytes in nevus skin stimulate hair growth

August 2023 in “Journal of Investigative Dermatology”

Senescent melanocytes in nevus skin boost hair growth.

research `Cyclic alopecia' inMsx2mutants: defects in hair cycling and hair shaft differentiation

158 citations , December 2002 in “Development”

Msx2-deficient mice experience irregular hair growth and loss due to disrupted hair cycle phases.

research Micro‐RNA‐31 controls hair cycle‐associated changes in gene expression programs of the skin and hair follicle

149 citations , June 2010 in “The FASEB journal”

miR-31 regulates hair growth by controlling gene expression in hair follicles.

research A new path in defining light parameters for hair growth: Discovery and modulation of photoreceptors in human hair follicle

70 citations , April 2017 in “Lasers in surgery and medicine”

Blue light promotes hair growth by interacting with specific receptors in hair follicles.

research The hair cycle on the human thigh and upper arm

67 citations , July 1985 in “British journal of dermatology/British journal of dermatology, Supplement”

Men's thigh hair grows longer and has a longer growth cycle than women's, but arm hair growth is similar between genders.

research Premature termination of hair follicle morphogenesis and accelerated hair follicle cycling in Iasi congenital atrichia (fz^ica) mice points to fuzzy as a key element of hair cycle control

20 citations , July 2005 in “Experimental dermatology”

The fuzzy gene is crucial for controlling hair growth cycles.

research Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness

12 citations , September 2021 in “PLoS ONE”

WNT10A and EBF1 interaction affects hair growth in male-pattern baldness.

A Comparative In Vivo and In Vitro Evaluation of Hair Growth Potential of Extracts and an Isolate from Petroleum Ether Extract of Cuscuta Reflexa Roxb

research A comparative in vivo and in vitro evaluation of hair growth potential of extracts and an isolate from petroleum ether extract of Cuscuta reflexa Roxb

7 citations , September 2014 in “Beni-Suef University Journal of Basic and Applied Sciences”

Cuscuta reflexa extracts and an isolate promoted hair growth and could be natural treatments for hair loss.