research Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus
Lenalidomide effectively and safely treats skin symptoms in pediatric lupus, reducing the need for prednisone.
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research Alopecia Universalis Associated with Ulcerative Colitis and The Role of Azathioprine
A man with complete hair loss and ulcerative colitis regrew hair after treatment with azathioprine.
research Childhood‐onset systemic lupus erythematosus with trisomy X and the increased risk for bone complications: a case report
A girl with lupus and trisomy X has a higher risk of bone problems like avascular necrosis and osteoporosis.
research SLE classification criteria item relationships: implications on SLE as a disease entity
SLE is likely one disease with various symptoms, not multiple distinct diseases.
research MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.
research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin
PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.
research Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model
Proton minibeam radiotherapy may reduce skin side effects by causing localized DNA damage.
research Case Report: Rowell Syndrome–Like Flare of Cutaneous Lupus Erythematosus Following COVID-19 Infection
COVID-19 may trigger severe skin flare-ups in people with autoimmune conditions like lupus.
research Type 2 Cytokine–Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study
AD-derived keratinocytes effectively mimic inflammation in atopic dermatitis.
research Osteogenic Potential of Mesenchymal Stem Cells from Adipose Tissue, Bone Marrow and Hair Follicle Outer Root Sheath in a 3D Crosslinked Gelatin-Based Hydrogel
Stem cells from hair follicles in a special gel show strong potential for bone regeneration.
research First‐degree relatives of patients with systemic lupus erythematosus: Autoreactivity but not autoimmunity?
Relatives of lupus patients show signs of immune system activity but not full-blown lupus.
research Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology
Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.
research Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling
The study investigates the efficacy of a compound, FR-1, in reducing skin scarring and promoting regeneration through mitochondrial uncoupling. Tested on scar-derived fibroblasts from 6 patients and in a murine wound model, FR-1 significantly reduced scar size and preserved hair follicles without adverse effects like skin atrophy or hair follicle damage, unlike current therapies such as triamcinolone acetonide (TA). FR-1 works by inhibiting fibroblast proliferation and remodeling the extracellular matrix, showing potential for broader applications in fibrosis treatment. The compound demonstrated enhanced stability and solubility, with minimal systemic absorption and no adverse effects on major organs, suggesting its potential as a therapeutic agent for scarless healing.
research Periplaneta americana extract (L.) promotes hair regrowth in Alopecia areata mice by reducing inflammation and modulating skin microbiota
Periplaneta americana extract helps hair regrowth by reducing inflammation and improving skin bacteria balance.
research Effect of two shampoo formulations on the prokaryotic and eukaryotic microbiota composition of the human scalp
Both shampoos increased scalp germ numbers but did not change the overall microbial community composition.
research Effects of the α-ketoglutaric acid on the performance, hair follicle development and antioxidant capacity of Rex rabbits
α-Ketoglutaric acid improves hair growth, rabbit performance, and antioxidant levels.
research Worldwide cohort study of 46, XY differences/disorders of sex development genetic diagnoses: geographic and ethnic differences in variants
About 50% of 46, XY DSD cases lack a genetic diagnosis, but advanced sequencing methods improve detection.
research Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy
CO2 laser treatment for aging skin significantly changes immune system-related genes.
research Human adipose tissue–derived mesenchymal stromal cells and their phagocytic capacity
HAT-MSCs can effectively engulf harmful microbes and particles, aiding infection treatment.
research Role of EZH2 in Uterine Gland Development
EZH2 is crucial for uterine gland development and female fertility.
research Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin
Laser therapy on human skin affects the HERC6 gene and related genes, influencing many cell processes and requiring careful safety measures.
research Enzymes
Enzymes play crucial roles in metabolism, health, and disease management.
research Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus
The new SLICC criteria for diagnosing lupus are more sensitive and accurate than the old criteria.
research Late-Onset Systemic Lupus Erythematosus
Older adults diagnosed with lupus show less severe symptoms but have a lower survival rate, often due to age-related factors.
research Vitamin D and the Skin: An Update for Dermatologists
Adequate vitamin D is crucial for skin health and should be considered in dermatology.
research Immunosuppressive treatment for proliferative lupus nephritis
Mycophenolate mofetil may improve lupus nephritis remission more than cyclophosphamide but with uncertain safety.
research PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus
Tph cells are linked to the severity of systemic lupus erythematosus.
research The genetics of alopecia areata: New approaches, new findings, new treatments
New genetic discoveries may lead to better treatments for alopecia areata.
research Possible protective effect of hydroxychloroquine on delaying the occurrence of integument damage in lupus: LXXI, data from a multiethnic cohort
Hydroxychloroquine may help delay skin damage in lupus patients.
research The Role of Sex and Gender in Dermatology - From Pathogenesis to Clinical Implications
Understanding sex and gender differences can improve personalized dermatology care.