July 2022 in “Journal of Investigative Dermatology” The combination of a plant extract and a peptide can increase hair pigmentation and may reverse greying.
127 citations
,
November 2010 in “Pigment cell & melanoma research” We need more research on human hair follicle pigmentation, not just mouse models.
April 2016 in “Journal of Investigative Dermatology” Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.
The microenvironment affects the behavior and survival of melanocytes with the GNAQ oncogene in melanoma.
April 2018 in “Journal of Investigative Dermatology” The research found that a specific skin cell type not only triggers hair growth but also controls hair color, and that aging can lead to hair loss and color changes.
April 2026 in “Biomolecules” Squid ink melanin nanoparticles create a safe, long-lasting black hair dye that protects hair and offers UV protection.
20 citations
,
February 2023 in “Biology” Innovative cosmetics could safely change hair color by targeting biological hair pigmentation processes.
2 citations
,
November 2024 in “JAAD reviews.” Certain drugs can change hair color, either lightening or darkening it.
June 2025 in “BMJ Case Reports” Axitinib treatment turned a man's grey hair back to black.
38 citations
,
June 2005 in “Acta Biochimica Polonica” Splenic eumelanin in C57BL/6 mice is different from hair eumelanin.
11 citations
,
January 2016 in “Evidence-based Complementary and Alternative Medicine” Rice bran extract can increase melanin production and may help treat melanin deficiency.
2 citations
,
January 2023 in “International journal of biological sciences” Gray hair can potentially be reversed, leading to new treatments.
1 citations
,
December 2015 in “Journal of the Medical Sciences (Berkala Ilmu Kedokteran)” Transplanting melanocyte stem cells from hair follicles can effectively treat vitiligo.
22 citations
,
January 1985 in “Journal of Human Evolution/Journal of human evolution” Human skin and hair color variation is mainly due to melanin produced by a few genes, with melanin protecting against sun damage.
4 citations
,
March 2024 in “Journal of Investigative Dermatology” SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.
8 citations
,
June 2016 in “Journal of Cutaneous Pathology” Two women were diagnosed with a rare melanoma that looked like hair loss but was actually a type of skin cancer.
4 citations
,
October 2019 in “Skin Appendage Disorders” Gefitinib can cause hair and eyebrow darkening.
January 2026 in “Current Issues in Molecular Biology” miR-5110 affects alpaca pigmentation by altering specific gene expressions.
October 2023 in “European journal of dermatology/EJD. European journal of dermatology” Injectable platelet-rich fibrin can safely and effectively treat melasma.
57 citations
,
February 1994 in “Experimental dermatology” Melatonin affects mouse skin and may regulate skin functions.
1 citations
,
November 2023 in “BMC chemistry” Tadalafil and Finasteride may help treat aggressive melanoma.
4 citations
,
February 2025 in “Pharmaceuticals” Voglibose may help treat skin hyperpigmentation safely.
January 2025 in “Archives of Dermatological Research”
April 2023 in “Australasian Journal of Dermatology” Lentiginous melanoma is most common on the face, especially the nose, cheek, and pre-auricular areas, with men more likely to have it on the scalp, ears, upper back, and trapezius, and women on the cheek and anterior arm. Sun damage is a key factor in its formation.
Adenophora Radix extract can promote hair growth and increase melanin in mice.
April 2026 in “npj Regenerative Medicine” Melanocyte stem cells in hair follicles are key to understanding and potentially preventing hair graying.
260 citations
,
June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
Azelaic acid helps with skin pigmentation issues, but its full effects are not completely understood.
January 2022 in “International Journal of Nutrology” Diet and nutrients, including lycopene from tomatoes and hydroquinone from wheat, can help control melasma, a skin condition.
1 citations
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April 2016 in “Journal of The American Academy of Dermatology” Blood pressure medications may increase the risk of skin cancer.