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Did you mean Aromatase Inhibitors?

GlossaryAromatase Inhibitors

block estrogen production by inhibiting the aromatase enzyme

Aromatase Inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels, AIs are commonly used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women, as estrogen can promote the growth of certain types of breast cancer cells.

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research Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy

90 citations , December 2007 in “Current Oncology”

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

research Reduced estradiol synthesis by letrozole, an aromatase inhibitor, is protective against development of pentylenetetrazole-induced kindling in mice

14 citations , October 2015 in “Neurochemistry International”

Letrozole may help prevent seizures by reducing certain hormone levels.

research Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice

11 citations , April 2018 in “Epilepsy research”

Letrozole reduces seizures but not brain damage in mice.

Androgenic Efficacy and Mechanism of Glycosides-Based Standardized Fenugreek Seeds Extract Through Aromatase and 5-Alpha Reductase Inhibition

research Androgenic Efficacy and Mechanism of Glycosides-Based Standardized Fenugreek Seeds Extract Through Aromatase And 5-Alpha Reductase Inhibition

1 citations , February 2024 in “Pharmacognosy Journal”

Fenugreek seed extract boosts testosterone and improves male reproductive health without heart side effects.

research Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor

44 citations , December 2005 in “The Journal of Steroid Biochemistry and Molecular Biology”

Combining 5α-reductase and aromatase inhibitors may better reduce estrogen levels.

The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

research The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana tropicalis

37 citations , January 2009 in “Sexual Development”

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

research Aromatase inhibitor–induced hair loss in two adolescents

1 citations , September 2020 in “Pediatric Dermatology”

Two teenage boys lost hair after taking a drug for growth, which was not a known side effect for kids.

research A case of aromatase inhibitor‐induced alopecia successfully treated with low‐dose oral minoxidil

March 2023 in “Journal of Cosmetic Dermatology”

Low-dose oral minoxidil improved hair growth when topical treatments failed.

research Aromatase inhibitor therapy and hair loss among breast cancer survivors

34 citations , November 2013 in “Breast Cancer Research and Treatment”

Aromatase inhibitor therapy for breast cancer increases the risk of hair loss and thinning.

research CDK4/6 plus aromatase inhibitor-induced alopecia in breast cancer patients.

4 citations , May 2019 in “Journal of Clinical Oncology”

Some breast cancer treatments cause hair loss similar to male pattern baldness, which can be improved with minoxidil.

research SAT-288 Successful Virilization of a PAIS Patient with a Missense Mutation In The Ligand-binding Domain Of The Androgen Receptor with Combined High-dose Testosterone and Aromatase Inhibitor

April 2019 in “Journal of the Endocrine Society”

A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

Amiodarone-Induced Toxic Epidermal Necrolysis; Nilotinib-Associated Cerebrovascular Disease and Stroke; Pisa Syndrome Caused by Paliperidone; Macroglossia Associated with Methylprednisolone; Aromatase Inhibitor-Induced Male Pattern Baldness in Women; Acute Liver Failure Due to Etodolac

research Amiodarone-Induced Toxic Epidermal Necrolysis; Nilotinib-Associated Cerebrovascular Disease and Stroke; Pisa Syndrome Caused by Paliperidone; Macroglossia Associated with Methylprednisolone; Aromatase Inhibitor-Induced “Male Pattern Baldness” in Women? Acute Liver Failure Due to Etodolac

August 2013 in “Hospital Pharmacy”

Certain medications can cause serious side effects, including skin reactions, stroke, muscle disorders, tongue swelling, hair loss in women, and liver failure.

research Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats

13 citations , December 2010 in “Pharmacology Biochemistry and Behavior”

Inhibiting certain enzymes made female rats more sensitive to low-level pain.

research The Safety of Local Hormonal Treatment for Vulvovaginal Atrophy in Women With Estrogen Receptor-positive Breast Cancer Who Are on Adjuvant Aromatase Inhibitor Therapy: Meta-analysis

18 citations , August 2019 in “Clinical breast cancer”

Local hormonal treatment for vulvovaginal atrophy is likely safe for women with estrogen receptor-positive breast cancer on aromatase inhibitors.

Neonatal Inhibition of Androgen Activity Alters the Programming of Body Weight and Orexinergic Peptides Differentially in Male and Female Rats

research NEONATAL INHIBITION OF ANDROGEN ACTIVITY ALTERS THE PROGRAMMING OF BODY WEIGHT AND OREXINERGIC PEPTIDES DIFFERENTIALLY IN MALE AND FEMALE RATS

February 2024 in “Brain research bulletin”

Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.

Effects of Chronic Inhibition of Testosterone Metabolism on Cardiac Remodeling After Ischemia/Reperfusion-Induced Myocardial Damage in Gonadectomized Rats

research Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats

4 citations , May 2019 in “Biology open”

Testosterone reduces heart damage and inflammation after injury.

research Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol

136 citations , January 2004 in “Neuroscience”

Testosterone increases seizure risk through its conversion to specific neurosteroids.

research The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites

19 citations , July 2018 in “Medicines”

Juniperus plants contain compounds with potential for developing various medical treatments.

research Endocrine treatment of benign prostatichypertrophy: Current concepts

11 citations , January 1991 in “Urology”

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

research A Comprehensive Review on Phytochemistry and Pharmacological Effects of Stinging Nettle (Urtica dioica)

8 citations , May 2017 in “Current traditional medicine”

Stinging nettle has compounds that help with joint pain, arthritis, and prostate issues.

research Drug safety evaluation of exemestane

7 citations , March 2011 in “Expert Opinion on Drug Safety”

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

Early Androgen Activity After Birth Determines the Hypothalamic Expression of Androgen and Estrogen Receptors in Adulthood in Female but Not in Male Rats

research Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

July 2025 in “Reproductive Biology and Endocrinology”

Early androgen exposure affects hormone receptor expression in adult female rats' brains, but not in males.

research SUN-118 A Case of Anastrozole Induced Hyperandrogenism

October 2025 in “Journal of the Endocrine Society”

Anastrozole can cause increased testosterone, leading to symptoms like hair growth and thinning.

research Androgens and ovarian function: translation from basic discovery research to clinical impact

55 citations , May 2019 in “Journal of Endocrinology”

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

research Cellular actions of testosterone in vascular cells: Mechanism independent of aromatization to estradiol

55 citations , June 2012 in “Steroids”

Testosterone affects vascular cells directly without converting to estradiol.

research Formestane Preferred as Second-Line Therapy in Advanced Breast Cancer

May 1993 in “Drugs & Therapy Perspectives”

Formestane is a preferred second-line treatment for advanced breast cancer in postmenopausal women because it's effective and has fewer side effects.

research Update on polycystic ovary syndrome

4 citations , August 2021 in “Clinical and Experimental Reproductive Medicine”

The 2018 guideline for PCOS suggests new diagnostic criteria and treatments, but recognizes the need for more research.