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A Microscopy-Based Small Molecule Screen in Primary Neurons Reveals Neuroprotective Properties of the FDA-Approved Anti-Viral Drug Elvitegravir

research A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir

3 citations , September 2020 in “Molecular Brain”

The anti-viral drug Elvitegravir may protect brain cells from damage related to neurodegenerative diseases.

research Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2

29 citations , November 2021 in “FEBS Open Bio”

Cepharanthine analogues, especially tetrandrine, show potential for treating COVID-19.

Single Nucleotide Polymorphisms Associated with Elevated Alanine Aminotransferase in Patients Receiving Asunaprevir Plus Daclatasvir Combination Therapy for Chronic Hepatitis C

research Single nucleotide polymorphisms associated with elevated alanine aminotransferase in patients receiving asunaprevir plus daclatasvir combination therapy for chronic hepatitis C

2 citations , July 2019 in “PLOS ONE”

Certain genetic variations are linked to higher liver enzyme levels in patients treated for chronic hepatitis C with specific drugs.

research Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies

77 citations , July 2020 in “European Journal of Clinical Pharmacology”

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

60 citations , December 2013 in “PLoS ONE”

EETs can delay seizures by affecting GABA activity, offering potential new treatments for seizures.

research Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods

42 citations , April 2021 in “Pharmaceuticals”

Five FDA-approved drugs may help block COVID-19 virus entry.

research Azathioprine-induced liver injury in a patient with multiple autoimmune syndrome

7 citations , May 2010 in “Journal of Dermatological Treatment”

A man with multiple autoimmune diseases developed liver injury from azathioprine, but his liver improved after stopping the drug.

Developing New Dual-Action Antiviral/Anti-Inflammatory Small Molecules for COVID-19 Treatment Using In Silico and In Vitro Approaches

research DEVELOPING NEW DUAL-ACTION ANTIVIRAL/ANTI-INFLAMMATORY SMALL MOLECULES FOR COVID-19 TREATMENT USING IN SILICO AND IN-VITRO APPROACHES

November 2024

Hit15 shows promise as a COVID-19 treatment by reducing virus infection and inflammation.

research Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis

137 citations , December 2006 in “Arthritis Research & Therapy”

Mycophenolate mofetil is safer and more effective than cyclophosphamide for treating lupus nephritis.

research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

13 citations , January 2015 in “Steroids”

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

research Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity

13 citations , October 2017 in “Bioorganic & Medicinal Chemistry”

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors and Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

research Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

9 citations , May 2021 in “Molecules”

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

research Predictive factors for therapeutic response and cluster analysis in syndrome of undifferentiated recurrent fever (SURF)

2 citations , July 2025 in “RMD Open”

IL-1 blockade is effective for treating SURF, and personalized treatment is needed.

research Advances in nucleoside monophosphate prodrugs as anti-HCV agents

52 citations , October 2010 in “Antiviral Therapy”

New treatments for Hepatitis C show promise but need more research to confirm their safety and effectiveness for clinical use.

research Targeting PrfA from Listeria monocytogenes: a computational drug repurposing approach

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research suggests Dutasteride and Solifenacin may be effective against the bacterium causing listeriosis.

research Synthesis and anticancer activity evaluation of Novel 6 mercaptopurine derivatives.

January 2015 in “Journals & Books Hosting (International Knowledge Sharing Platform)”

Compound 1 showed promising anticancer activity.

Repurposing Finasteride And Serotonin Reuptake Inhibitors As Novel Antimicrobials: A Dual-Action Approach To Target Bacterial And Fungal Pathogens

research Repurposing Finasteride and Serotonin Reuptake Inhibitors as Novel Antimicrobials: A Dual-Action Approach to Target Bacterial and Fungal Pathogens

March 2026 in “Frontiers in Bioscience-Elite”

Duloxetine, escitalopram, and finasteride may be effective against bacteria and fungi.

research Most recent findings of curative drugs for lower urinary tract symptoms in clinical practice

January 2019 in “Nihon Yakuri Gakkai nenkai yoshishu”

Current treatments for lower urinary tract symptoms include α1-blockers, 5ARIs, PDE5 inhibitors, anticholinergic agents, and β3-adrenergic receptor agonists.

research 5α-Reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives

26 citations , October 2011 in “International Journal of Biological Macromolecules”

Some newly made compounds are promising for treating enlarged prostate, hair loss, viruses, and prostate cancer, and might be better than current drugs.