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Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research Immunomodulatory Potential of a Bibenzyl-dihydrophenanthrene Derivative Isolated from Calanthe cardioglossa

3 citations , January 2025 in “Journal of Natural Products”

Calancardin B may help reduce inflammation in immune cells.

research Polymer conjugated retinoids for controlled transdermal delivery

36 citations , July 2017 in “Journal of controlled release”

A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with fewer side effects.

research S125 Topical treatment of androgenetic alopecia with spironolactone

2 citations , September 1997 in “Journal of The European Academy of Dermatology and Venereology”

Topical spironolactone effectively treats hair loss in women.

research Platycladus orientalis Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation

October 2024 in “Current Issues in Molecular Biology”

Platycladus orientalis leaf extract helps hair grow by activating certain proteins.

research The efficacy of an adjuvant norethisterone (jenapharm) therapy in endometrial cancer

January 1987 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry”

Norethisterone (jenapharm) therapy is effective for endometrial cancer.

research 198 Dutasteride for men with androgenic alopecia unresponsive to finasteride

August 2016 in “Journal of Investigative Dermatology”

research Minoxidil for severe hypertension after failure of other hypotensive drugs.

86 citations , September 1977 in “BMJ”

Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.

Assessment of the Efficacy and Tolerability of a Topical Formulation Containing Caffeine and Procapil 3% for Improvement of Male Pattern Hair Loss

research Assessment of the efficacy and tolerability of a topical formulation containing caffeine and Procapil 3% for improvement of male pattern hair loss

November 2023 in “Journal of Cosmetic Dermatology”

The topical treatment with caffeine and Procapil 3% improved male pattern hair loss and was well tolerated after 12 weeks.

Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

research Metabolism of Minoxidil, a New Hypotensive Agent 11: Biotransformation following Oral Administration to Rats, Dogs, and Monkeys

31 citations , August 1975 in “Journal of Pharmaceutical Sciences”

Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

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