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GlossaryAtrophy

gradual decline or shrinkage of tissue or organ

Atrophy refers to the gradual decline or shrinkage of tissue or an organ due to a reduction in cell size or number. In the context of hair and alopecia, atrophy can involve the thinning of the scalp or hair follicles, leading to hair loss or reduced hair density. This process can be caused by various factors, including aging, hormonal changes, or underlying medical conditions.

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Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

research Combined autologous platelet-rich plasma with microneedling verses microneedling with distilled water in the treatment of atrophic acne scars: a concurrent split-face study

106 citations , January 2016 in “Journal of Cosmetic Dermatology”

Using platelet-rich plasma with microneedling works better for acne scars than microneedling with water.

Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans

research 'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans

47 citations , July 2005 in “British Journal of Dermatology”

Topical vitamin D3 does not prevent hair loss from chemotherapy.

research Dermatitis cruris pustulosa et atrophicans revisited: our experience with 37 patients in south India

14 citations , September 2009 in “International Journal of Dermatology”

DCPA is a chronic leg infection often related to Staphylococcus aureus, affecting mostly young men in India.

research Dermatitis cruris pustulosa et atrophicans

11 citations , January 2009 in “Indian journal of dermatology, venereology, and leprology”

DCPA is a chronic skin condition affecting the lower limbs, mainly in men, with unclear causes and treatments that often don't work well.

Study to Compare the Efficacy of 50% Glycolic Acid with 65% Trichloroacetic Acid in the Treatment of Atrophic Acne Scars by CROSS Technique

research Study to compare the efficacy of 50% glycolic acid with 65% trichloroacetic acid in the treatment of atrophic acne scar by CROSS technique

1 citations , August 2024 in “Journal of Cutaneous and Aesthetic Surgery”

65% TCA improves acne scars more but has more side effects than 50% GA.

research Combined treatment modalities in atrophic acne scars: a prospective study

February 2019 in “International journal of research in dermatology”

The combined treatments were highly effective for improving atrophic acne scars.

Atrophying Squamous Papulous Dermatitis (Degos Disease): Nine Years of Follow-Up

research Atrophying scamous papulous dermatitis (Degos disease): Nine years of follow-up

February 2010 in “Journal of The American Academy of Dermatology”

A woman with Degos disease managed her condition for nine years with medications and had two healthy pregnancies, while a separate finding suggests a possible link between female pattern hair loss and high blood pressure.

research Use of Condensed Nanofat Combined With Fat Grafts to Treat Atrophic Scars

62 citations , October 2017 in “JAMA facial plastic surgery”

Condensed nanofat with fat grafts effectively improves atrophic facial scars.

research The efficacy in treatment of facial atrophic acne scars in Asians with a fractional radiofrequency microneedle system

51 citations , September 2013 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

FRMS is a safe and effective treatment for acne scars in Asians with minimal side effects.

research Serial sections of atrophic acne scars help in the interpretation of microscopic findings and the selection of good therapeutic modalities

36 citations , November 2011 in “Journal of the European Academy of Dermatology and Venereology”

Effective acne scar treatment should use combination therapy based on specific skin changes.

research A Meta-analysis of the Evidence for Assisted Therapy with Platelet-Rich Plasma for Atrophic Acne Scars

16 citations , September 2019 in “Aesthetic Plastic Surgery”

Platelet-rich plasma therapy helps improve atrophic acne scars.

research Atrophic Diseases of the Adnexa

15 citations , July 2005

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research Unilateral keratosis pilaris atrophicans faciei mimicking follicular mucinosis

3 citations , April 2011 in “Journal of the American Academy of Dermatology”

A 19-year-old man had a rare skin condition on one side of his face that looked like another skin disease.

research Use of Microneedling with Platelet Rich Plasma for Management of Atrophic Post-Acne Scars: Review Article

1 citations , April 2023 in “The Egyptian Journal of Hospital Medicine”

Microneedling with PRP effectively improves atrophic acne scars.

Fluid Platelet-Rich Fibrin Versus Platelet-Rich Plasma in the Treatment of Atrophic Acne Scars: A Comparative Study

research Fluid Platelet-Rich Fibrin (PRF) Versus Platelet-Rich Plasma (PRP) in the Treatment of Atrophic Acne Scars: A Comparative Study

1 citations , December 2022 in “Archives of Dermatological Research”

Fluid Platelet-Rich Fibrin (PRF) is more effective and faster at improving acne scars than Platelet-Rich Plasma (PRP), with similar mild side effects.

Efficacy and Safety of Autologous Cell-Based Therapies for Atrophic Acne Scar Treatment: An Updated Systematic Review and Meta-Analysis with In-Depth Methodological and Clinical Insights

research Efficacy and safety of autologous cell-based therapies for atrophic acne scar treatment: an updated systematic review and meta-analysis with in-depth methodological and clinical insights

March 2026 in “Frontiers in Cell and Developmental Biology”

Autologous cell-based therapies, especially SVF, effectively and safely improve atrophic acne scars.

research Human insulin via MMP® for treating atrophic acne scars: a pilot study Insulina humana via MMP® para cicatrizes atróficas de acne: estudo piloto.

January 2026 in “International Journal of Health Science”

Human insulin via microinfusion may effectively improve atrophic acne scars.

research Dermatoscopic Patterns in Keloid, Hypertrophic, and Atrophic Scars: Cross-Sectional Analysis and Clinical Correlation

October 2025 in “Dermatology Practical & Conceptual”

Dermatoscopy helps track scar changes and guide treatment.

research Synergistic Effects of Fractional CO ₂ Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling

January 2025 in “Dermatologic Therapy”

Combining fractional CO₂ laser with type III collagen improves acne scar treatment.

research Role of platelet rich plasma therapy in the treatment of alopecia areata and atrophic acne scars

June 2024 in “IP Indian journal of clinical and experimental dermatology”

PRP therapy effectively treats alopecia areata and atrophic acne scars.

research Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars

February 2024 in “Australasian journal of dermatology”

Inflammatory acne damages skin stem cells and reduces their growth, leading to atrophic acne scars.

research Multiple facial atrophic scars in childhood

February 2024 in “Pediatric Dermatology”

A 5-year-old girl with a rare genetic disorder, lipoid proteinosis, showed reduced new lesions but persistent scars after avoiding skin trauma.

Comparison of 1064-nm Nd:YAG Picosecond Lasers Using Fractional Micro-Lens Array vs. Ablative Fractional 2940-nm Er:YAG Lasers for the Treatment of Atrophic Acne Scar in Asians: A 20-Week Prospective, Randomized, Split-Face, Controlled Trial

research 604 Comparison of 1064-nm Nd:YAG picosecond lasers using fractional micro-lens array vs. ablative fractional 2940-nm Er:YAG lasers for the treatment of atrophic acne scar in Asians: A 20-week prospective, randomized, split-face, controlled trial

April 2023 in “Journal of Investigative Dermatology”

Both laser treatments improved acne scars similarly, but the Nd:YAG laser was safer and less painful, while the Er:YAG laser left patients slightly more satisfied.

research Updated Management of Atrophic Post Acne Scars: Review Article

October 2021 in “The Egyptian Journal of Hospital Medicine ”

Combination therapies work better than single treatments for atrophic acne scars.

research Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism

135 citations , December 2006 in “PLoS Medicine”

Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.

Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations , August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Skin Physiology in Microgravity: A 3-Month Stay Aboard ISS Induces Dermal Atrophy and Affects Cutaneous Muscle and Hair Follicles Cycling in Mice

research Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice

48 citations , May 2015 in “NPJ microgravity”

A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.