research Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies
Extracellular vesicles show promise for treating diseases but face challenges in development and regulation.
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180-210 / 1000+ results research Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress
Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.
research Protective Effects of Melatonin on the Skin: Future Perspectives
Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.
research Serum Ferritin Levels: A Clinical Guide in Patients With Hair Loss
Low ferritin levels can indicate iron deficiency as a cause of hair loss.
research FLCN regulates transferrin receptor 1 transport and iron homeostasis
FLCN helps control iron levels in cells.
research Translating Resveratrol Research: A Systematic Review on Patents and Clinical Trials (2000–2025)
Resveratrol shows health benefits but faces challenges in effectiveness and regulation.
research Can nanozymes make the leap to the clinic? Advances, hurdles, and prospects
Nanozymes have potential for medical use but face challenges like safety and regulation.
research Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
Par3 protein is essential for skin cell balance and stability.
research 602 mTORC1 activity controls human scalp hair follicle pigmentation and growth
mTORC1 activity is important for hair growth and color, and targeting it could help treat hair loss and greying.
research The TOR–Auxin Connection Upstream of Root Hair Growth
High energy boosts root hair growth in plants, while low energy stops it.
research PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis
Increasing PBX1 reduces aging and cell death in hair follicle stem cells by boosting SIRT1 and lowering PARP1 activity.
research Potential therapeutic applications of mesenchymal stem cell-derived extracellular vesicles
MSC-derived EVs have potential as therapeutic agents but face challenges like production complexity and high costs.
research Decoding Hyperpigmentation from Biological Mechanisms to Actives with Clinically Proven Topical Efficacy: A Narrative Review
Combining multiple ingredients is the most effective treatment for hyperpigmentation.
research Causality of Aging Hallmarks
Lengthening telomeres may reverse aging and extend lifespan.
research The Role of Vimentin in Tissue Repair and Cell Growth
Vimentin is crucial for wound healing, cell growth, and managing immune responses.
research Tregs: Where We Are and What Comes Next?
The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.
research Transcriptome profiling of whisker follicles in methamphetamine self-administered rats
Methamphetamine affects gene expression in rat whisker follicles, with key genes linked to addiction.
research Potent Efficacy of Computer-Aided Designed Peptide Degrader Drug on PCSK9-Mediated Hypercholesterolemia
Cadd4 effectively reduces cholesterol levels without side effects.
research DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging
ZDHHC17 methylation may help treat or identify facial skin aging.
research The Effects of Physical Activity on Skin Health: A Narrative Review
Moderate exercise improves skin health, but intense exercise without protection can harm it.
research Epidermal Wnt/beta-catenin signalling promotes dermal adipocyte differentiation during hair follicle morphogenesis and regeneration
Wnt/beta-catenin signaling in the skin helps fat cell development during hair growth and repair.
research Repurposed Drugs: Current Trends in Drug Discovery
Drug repurposing speeds up development, cuts costs, and uses known safe drugs, but faces challenges like regulations and patents.
research Exploring the Mechanism of Platycladi Cacumen in Intervening Androgenetic Alopecia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation
Platycladi Cacumen may help treat hair loss by targeting specific proteins and pathways.
research Copy number variation regions in Nellore cattle: Evidences of environment adaptation
Nellore cattle have genetic variations linked to their adaptation to tropical environments.
research Transcriptomes reveal microRNAs and mRNAs in different photoperiods influencing cashmere growth in goat
Different amounts of daylight affect cashmere growth in goats by changing the activity of certain genes and molecules.
research Protective mitophagy in human hypoxic cardiomyocytes: mechanistic insights into SGLT2 inhibitor Dapagliflozin cardioprotection in ischemic injury
Dapagliflozin helps protect heart cells under stress by improving mitochondrial function and reducing cell damage.
research Polymeric nanocapsular baicalin: Chemometric optimization, physicochemical characterization and mechanistic anticancer approaches on breast cancer cell lines
Baicalin nanocapsules greatly enhance its anticancer effects on breast cancer cells.
research Molecular basis of hair cell loss
The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.
research Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation
PRP injections improve facial skin by reducing wrinkles and pores.
research Oncogenic senescence: a multi-functional perspective
Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.