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Glossary4-azasteroid

synthetic compound mimicking steroids with a nitrogen atom

A 4-azasteroid is a type of synthetic compound that mimics the structure of steroids but includes a nitrogen atom at the fourth position in its chemical structure. These compounds are often used in medical treatments to inhibit enzymes like 5-alpha-reductase, which can help manage conditions such as benign prostatic hyperplasia and androgenic alopecia (hair loss).

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research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin

34 citations , February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

research Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones

December 2016

The research created new azasteroids and pseudoazulenyl nitrones, which could be useful in medicine.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.

research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

13 citations , January 2015 in “Steroids”

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

research Synthesis of a 4-azasteroid hormones compound

January 2009 in “Xiandai huagong”

Finasteride was successfully synthesized from Pregnadienolone acetate.

research An overview on 5α-reductase inhibitors

219 citations , October 2009 in “Steroids”

5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.

research Recent advances in thiasteroids chemistry

37 citations , October 2006 in “Steroids”

New sulfur-containing steroid analogs show promise for more targeted medical treatments.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.

83 citations , April 1992 in “Journal of Biological Chemistry”

Four-amino acid part makes enzyme sensitive to finasteride.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research 12 Treatment of hirsutism with 5α-reductase inhibitors

28 citations , May 1986 in “Clinics in endocrinology and metabolism”

New compounds may soon be tested to treat excessive hair growth in women.

research 5α‐Reductase inhibitors and prostatic disease

21 citations , August 1994 in “Clinical endocrinology”

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

research Novel inhibitors of 5α-reductase

20 citations , February 2002 in “Expert Opinion on Therapeutic Patents”

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

research 5α-Reductase Inhibitors, Chemical and Clinical Models

17 citations , May 1998 in “Steroids”

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

research A Connection between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis

14 citations , May 2008 in “Journal of proteome research”

Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

research A concise review- Development of an analytical method and validation of dutasteride

January 2025 in “Current Trends in Pharmacy and Pharmaceutical Chemistry”

New methods for measuring dutasteride are effective and reliable.

research Dutasteride in Androgenetic Alopecia: An Update

27 citations , March 2017 in “Current Clinical Pharmacology”

Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.

research Alopecia - the search for novel agents continues

11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

research Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor.

7 citations , July 1995 in “PubMed”

Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.

research FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS

3 citations , December 2016 in “Universal journal of pharmaceutical research”

Finasteride, a drug used for anti-hyperplasia, can be effectively delivered in the form of matrix tablets.

research FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

April 2013 in “e-Jurnal Medika Udayana”

Finasteride effectively treats male pattern baldness.

research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

28 citations , September 2000 in “Journal of Medicinal Chemistry”

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

research Finasteride: The First 5α-Reductase Inhibitor

23 citations , July 1993 in “Pharmacotherapy”

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

193 citations , August 1985 in “Endocrinology”

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Determination of Finasteride in Tablet Form by Liquid Chromatography and Its Analytical Method Validation

research Determination of finasteride in the tablet form by liquid chromatography and its analytical method validation

11 citations , January 2006 in “Analytica Chimica Acta”

Validated method reliably measures finasteride in tablets using liquid chromatography.

research 5α-Reductase Inhibitors – The Finasteride Story

3 citations , October 2010 in “Wiley-VCH Verlag GmbH & Co. KGaA eBooks”

Finasteride safely treats enlarged prostate and male-pattern baldness.

research High-performance liquid chromatographic method for the determination of finasteride in human plasma at therapeutic doses

19 citations , May 1991 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Reliable method detects finasteride in human plasma at low doses.

research Effects of Long Term Treatment With Finasteride (MK-906), a 5-Alpha Reductase Inhibitor, on Circulating LH, FSH, Prolactin and Estradiol

10 citations , October 1992 in “Hormone and Metabolic Research”

Finasteride safely lowers DHT levels without affecting hormone levels, helping with conditions like enlarged prostate, acne, and hair loss.