31 citations
,
October 2016 in “PLoS ONE” The ubiquitin-mediated proteolysis pathway is crucial for hair follicle development in cashmere goats.
October 2025 in “Journal of Translational Medicine” Combining biomaterials and cell pathways can improve hair follicle regeneration.
86 citations
,
July 2020 in “International Journal of Molecular Sciences” Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.
94 citations
,
June 2016 in “The FASEB Journal” The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.
53 citations
,
May 2010 in “Journal of Cellular Physiology” Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.
42 citations
,
March 2014 in “European Journal of Pharmacology” Ginsenoside F2 from ginseng may increase hair growth better than standard treatments by affecting cell growth signals.
25 citations
,
August 2017 in “Animal Biotechnology” Researchers found that certain RNA molecules might play a role in the growth of Cashmere goat hair.
13 citations
,
August 2016 in “Medical Hypotheses” Hair characteristics might be early signs of Type 2 Diabetes and could help with early prevention.
11 citations
,
April 2020 in “Life sciences” Pantothenic acid helps mink hair follicles grow by affecting certain cell signals.
11 citations
,
March 2013 in “Journal of Applied Biomedicine” β-catenin helps hair follicle stem cells grow by activating a specific cell pathway.
5 citations
,
September 2018 in “Acta histochemica” The mTOR pathway proteins are altered in the hair follicles of patients with Lichen Planopilaris and Frontal Fibrosing Alopecia.
5 citations
,
October 2014 in “Methods” The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.
1 citations
,
April 2025 in “Pediatria i Medycyna Rodzinna” Restoring EDA and WNT pathways early may help improve skin, hair, and teeth issues in hypohidrotic ectodermal dysplasia.
1 citations
,
May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
February 2024 in “Frontiers in physiology” Modifying certain signals in the body can help wounds heal without scars and regrow hair.
November 2023 in “Frontiers in cell and developmental biology” Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.
39 citations
,
July 2021 in “Stem Cell Research & Therapy” Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.
5 citations
,
October 2025 in “International Journal of Nanomedicine” Traditional Chinese Medicine and biomaterials help heal chronic wounds by targeting multiple pathways.
136 citations
,
May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
89 citations
,
November 2017 in “Journal of Cellular Physiology” The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.
34 citations
,
June 2008 in “In vitro cellular & developmental biology. Animal” Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
21 citations
,
January 2023 in “The International Journal of Developmental Biology” The Wnt signaling pathway is crucial for regeneration and could help advance human medicine.
12 citations
,
June 2017 in “Cell Cycle” Minoxidil foam helps hair growth by increasing good proteins and decreasing bad pathways in men with hair loss.
March 2026 in “Dermatology and Therapy” Distinct miRNA signatures could help diagnose and treat severe Alopecia Areata.
2 citations
,
February 2014 in “Animal Biotechnology” The PTGER2 gene is highly active in Cashmere goat skin and its activity changes with the hair growth cycle.
April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.
20 citations
,
June 2010 in “Genes and Immunity” Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.
1 citations
,
April 2016 in “Journal of Investigative Dermatology” Blocking Prostaglandin D₂ may help treat hair loss.
15 citations
,
April 2017 in “Cell Stem Cell” Some brain cancer cells avoid immune system detection, and certain treatments could target this to slow their growth; also, certain fat cell precursors help regenerate hair and skin after injury.
12 citations
,
July 2025 in “Journal of Clinical and Translational Hepatology” TGF-β inhibitors may help treat liver fibrosis by targeting various pathways.