134 citations
,
July 2020 in “Experimental dermatology” Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.
114 citations
,
August 2002 in “Journal of Investigative Dermatology” Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.
69 citations
,
February 2008 in “The American journal of pathology” Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.
53 citations
,
July 2018 in “Drug design, development and therapy” Janus kinase inhibitors show promise in treating alopecia areata but need better topical formulations.
48 citations
,
April 2019 in “PloS one” Alopecia areata patients have more Propionibacterium acnes and less Staphylococcus epidermidis on their scalps.
47 citations
,
November 2012 in “Pharmaceutical research” Surface-modified nanoparticles mainly use non-follicular pathways to enhance skin permeation of ibuprofen and could improve treatment for inflammatory skin diseases.
45 citations
,
June 2018 in “Frontiers in immunology” MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.
29 citations
,
November 2011 in “Cell stress & chaperones” Quercetin effectively treated and prevented hair loss in mice.
16 citations
,
January 2022 in “International journal of molecular sciences” Certain daily habits like stress, diet, and sleep can affect the severity of hair loss in alopecia areata.
15 citations
,
March 2018 in “Cancer Medicine” Alopecia areata patients have varied cancer risks, with some cancers being lower and others higher.
15 citations
,
December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health” EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.
12 citations
,
November 2015 in “Journal of Investigative Dermatology Symposium Proceedings” PTH-CBD helps reduce hair loss in mice by stimulating hair growth directly.
11 citations
,
February 2003 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” Acne and increased body hair in teenage girls are normal but severe cases may need hormone evaluation and treatment can prevent diabetes linked to PCO.
9 citations
,
September 2009 in “Journal of Cutaneous Medicine and Surgery” UV light causes skin color loss in bald areas; wear a cap and use sunscreen.
4 citations
,
March 2025 in “Pediatric Dermatology” Pediatric alopecia areata needs more research to understand its characteristics and related conditions.
3 citations
,
June 2025 in “Biomedicines” Gut bacteria may influence hair loss in alopecia areata.
3 citations
,
July 2023 in “International journal of molecular sciences” Stress may contribute to hair loss in alopecia areata by affecting immune responses and cell death in hair follicles.
3 citations
,
April 2022 in “Microorganisms” People with severe hair loss (Alopecia Areata) have different scalp bacteria than healthy people, which might help predict the condition's progress.
2 citations
,
May 2025 in “Journal of Clinical Medicine” Upadacitinib is safe and effective for treating alopecia areata and atopic dermatitis in children.
2 citations
,
May 2025 in “Diagnostics” ATR-FTIR spectroscopy could help monitor alopecia areata treatment response non-invasively.
2 citations
,
April 2025 in “Biologics” Dupilumab and ustekinumab are promising treatments for alopecia areata, showing significant hair regrowth.
2 citations
,
June 2024 in “Journal of Clinical Medicine” Alopecia Areata can affect nails, often improving on its own, but JAK inhibitors may help.
2 citations
,
May 2022 in “Cosmetics” Further research is needed to understand how the microbiome affects hair loss in Alopecia Areata.
1 citations
,
April 2024 in “Journal of Clinical Medicine” Alopecia areata patients have eye issues and need regular eye exams.
1 citations
,
June 2023 in “Genes” Hair loss from Alopecia Areata is caused by both genes and environment, with several treatments available but challenges in cost and relapse remain.
1 citations
,
January 2022 in “Dermatology Research and Practice” Higher CD70 and CD27 gene expression in alopecia areata lesions predicts disease severity and activity.
May 2025 in “Frontiers in Pharmacology” Targeting gut microbiome and metabolome may help treat autoimmune skin diseases like alopecia areata.
February 2024 in “World journal of stem cells” Adipose-derived stem cells can help repair and improve eye tissues and appearance.
October 2017 in “Our Dermatology Online” DCP in isopropanol is better tolerated for treating alopecia areata.
Tofacitinib significantly regrows hair in severe alopecia without major side effects.