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research Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human

1 citations , January 2020 in “Microscopy research”

Researchers successfully grew hair follicle stem cells from mice and humans, which could be useful for tissue engineering and regenerative medicine.

research PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats

1 citations , April 2025 in “BMC Veterinary Research”

PSAT1 is key for hair growth and stem cell function in cashmere goats.

research 1393 Lower proximal cup cells but not bulge stem cells regenerate hair follicles after chemotherapy injury

1 citations , April 2018 in “Journal of Investigative Dermatology”

Lower proximal cup cells, not bulge stem cells, regenerate hair follicles after chemotherapy.

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors to Prevent Hair Loss from Chemotherapy or Radiation Therapy

research Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

March 2023

Activating certain cells in hair follicles can prevent hair loss caused by cancer treatments.

research 319 Mechanisms of cell death regulation in hair regeneration

October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking cell death in hair follicles can lead to impaired hair growth.

research Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model in vitro: implications for regenerative therapy of canine epidermis

11 citations , January 2013 in “Veterinary dermatology”

Keratinocytes from dog hair follicles can create a functional skin layer in a lab model, useful for dog skin therapy.

research Canine hair‐follicle keratinocytes enriched with bulge cells have the highly proliferative characteristic of stem cells

37 citations , October 2009 in “Veterinary Dermatology”

Canine hair follicles contain stem-like cells with high growth potential.

research Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

17 citations , July 2013 in “Amino Acids”

Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

research Current advances in stem cell-based therapies for hair regeneration

32 citations , May 2020 in “European Journal of Pharmacology”

Stem cell therapies show promise for hair regrowth but face production and application challenges.

research Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata

6 citations , March 2011 in “European Journal of Dermatology”

Nestin-positive cells are important for hair follicle regeneration in alopecia areata.

research Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker gene ID2, by contact sensitizers in human bulge‐derived keratinocytes

6 citations , January 2010 in “Journal of Biochemical and Molecular Toxicology”

The ID2 gene can help distinguish between sensitizers and irritants in skin cells.

research Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

March 2023

Boosting certain cell signals can prevent hair loss from chemotherapy and radiation.

research 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion

September 2019 in “Journal of Investigative Dermatology”

IL-17 and certain immune cells are linked to more severe alopecia areata.

research Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

Hair-follicle stem cells can become neurons.

research Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling

53 citations , February 2015 in “Journal of Investigative Dermatology”

Ceramide Synthase 4 is essential for normal hair growth and preventing hair loss.

research The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition during Root Hair Tip Growth

109 citations , February 2018 in “CB/Current biology”

ERULUS controls root hair growth by regulating cell wall composition and pectin activity.

research Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile

45 citations , December 2007 in “The FASEB journal”

There are two types of stem cells in rodent hair follicles, each with different keratin proteins.

research Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge

18 citations , March 2009 in “Experimental Dermatology”

Pilomatricoma can develop into various hair-related structures.

research Mouse Epidermal Neural Crest Stem Cell (EPI-NCSC) Cultures

3 citations , May 2008 in “Journal of Visualized Experiments”

Mouse Epidermal Neural Crest Stem Cells can become various cell types.

research 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia

1 citations , November 2022 in “Journal of Investigative Dermatology”

ALRN-6924 may prevent hair loss caused by chemotherapy.

research The dual role of stem cell-specific Bcl-2 function for epidermal regeneration and cancer

September 2019

Bcl-2 helps hair regeneration but can also increase cancer risk.

research Dissecting the bulge in hair regeneration

86 citations , February 2012 in “Journal of Clinical Investigation”

Stem cells in hair follicles are diverse and change throughout the hair cycle.

research 030 Impaired Glutathione Synthesis in Hair Follicle Stem Cell Niches in Alopecia Areata

November 2025 in “Journal of Investigative Dermatology”

Alopecia Areata may involve reduced antioxidant defenses in hair follicles, affecting stem cell function.

research The Progress of Epidermal Stem Cell Research

January 2010

Epidermal stem cells help renew skin and heal wounds, influenced by specific proteins and markers.

research Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations

23 citations , September 2013 in “Molecular Carcinogenesis”

Increased Stat3 activity reduces hair follicle stem cells and boosts other stem/progenitor cells.

research Dynamic interactions of lymphatic vessels at the hair follicle stem cell niche during hair regeneration

1 citations , February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

Lymphatic vessels are essential for hair follicle regeneration and growth.

research Faculty Opinions recommendation of Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia.

May 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

PPARgamma is crucial for healthy hair follicles, and its loss causes scarring alopecia.

research Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate in Vivo Epidermal Structures

10 citations , June 2016 in “Cell Transplantation”

Sebaceous glands can help harvest hair follicle stem cells to regenerate skin and hair.

Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

research Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets

29 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

Isoproterenol helps hair follicle stem cells turn into beating heart muscle cells.

research Deriving Keratinocyte Progenitor Cells and Keratinocytes from Human‐Induced Pluripotent Stem Cells

10 citations , August 2020 in “Current protocols in stem cell biology”

Scientists developed a way to create skin and hair cells from human stem cells, which could help treat burns and restore hair.

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