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Did you mean Protein Kinase A?

GlossaryProtein Kinase A

enzyme activated by cAMP that regulates various cellular processes

Protein Kinase A (PKA), also known as cAMP-dependent protein kinase, is an enzyme that plays a crucial role in regulating various cellular processes. It is activated by cyclic AMP (cAMP) and is involved in pathways that control cell growth, metabolism, and gene expression. PKA works by adding phosphate groups to specific proteins, which can alter their activity and function.

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Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells

research Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells.

August 1994 in “Molecular Endocrinology”

Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport

December 2023 in “Journal of ethnopharmacology”

Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.

research Steroidogenic factor-1 lineage origin of skin lesions in Carney complex syndrome

January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Skin lesions in Carney complex are likely caused by a specific group of skin cells that promote pigment production due to a genetic mutation.

research The Metabolism and Control Mechanism of Human Hair Follicles

22 citations , April 2015 in “Current problems in dermatology”

Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.

research Corticotropin-Releasing Factor Down-Regulates Hair Growth-Related Cytokines in Cultured Human Dermal Papilla Cells

1 citations , December 2014 in “Journal of the Society of Cosmetic Scientists of Korea”

CRF can cause hair loss, but blocking its receptors might prevent this.

research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation

60 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Applying a specific inhibitor lightens skin and hair color.

The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

72 citations , January 2003 in “American Journal of Pathology”

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

research Nerve growth factor regulates the proliferation of cashmere goat outer root sheath cells through the activation of cAMP-binding protein

1 citations , July 2019 in “Small ruminant research”

Nerve growth factor helps cashmere goat hair cells grow by activating a specific protein.

research A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis

280 citations , January 2004 in “The EMBO Journal”

AGC2-1 protein is essential for root hair growth in Arabidopsis.

Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

research Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia

June 2023 in “Frontiers in Medicine”

Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

research Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

76 citations , February 2007 in “Cancer Research”

Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.

research 126 cAMP response element-binding protein 1 (CREB) is a β-catenin-regulated transcription factor in squamous cell carcinoma (SCC) cells

April 2018 in “Journal of Investigative Dermatology”

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

research PAK4 signaling in health and disease: defining the PAK4–CREB axis

81 citations , February 2019 in “Experimental & Molecular Medicine”

PAK4 is crucial in cancer progression, brain development, and could be a therapeutic target, especially through the PAK4-CREB axis.

research 1325 Age-dependent loss of the stemness and antimicrobial defense function of dermal fibroblasts is mediated by TGFbeta

April 2018 in “Journal of Investigative Dermatology”

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

research Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells

March 2022 in “Molecules”

Adenosine can help treat hair loss by promoting hair growth.

research PKC downregulation upon rapamycin treatment attenuates mitochondrial disease

26 citations , December 2020 in “Nature metabolism”

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

research cis-Element- and Transcriptome-Based Screening of Root Hair-Specific Genes and Their Functional Characterization in Arabidopsis

188 citations , May 2009 in “Plant physiology”

Researchers found 19 genes important for root hair growth in a plant called Arabidopsis.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

The research found genes and miRNAs that may control hair growth in Forest Musk Deer.

research Enzymatic phosphorylation of hair keratin enhances fast adsorption of cationic moieties

11 citations , January 2016 in “International Journal of Biological Macromolecules”

Enzymatic phosphorylation of hair keratin improves the effectiveness of hair products with cationic ingredients.

research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

90 citations , December 2008 in “Journal of Investigative Dermatology”

Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.

research Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation

4 citations , February 2019 in “BioMed Research International”

Ebastine may promote hair regrowth by increasing cell growth through the ERK pathway.

Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

research Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets

3 citations , May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

research The IRE gene encodes a protein kinase homologue and modulates root hair growth in Arabidopsis

66 citations , May 2002 in “The Plant Journal”

The IRE gene is important for normal root hair growth in Arabidopsis plants.

research Proteome Analysis of Alpine Merino Sheep Skin Reveals New Insights into the Mechanisms Involved in Regulating Wool Fiber Diameter

October 2023 in “International journal of molecular sciences”

Key proteins and pathways regulate wool fiber diameter in Alpine Merino sheep.

research The effects of phosphodiesterase 3 (PDE3) inhibitor on hair follicle cell viability and hair growth

1 citations , January 2020 in “Seoul National University Open Repository (Seoul National University)”

PDE3 inhibitor may help treat hair loss by promoting hair growth.

Cold Atmospheric Microwave Plasma Stimulates Dermal Papilla Cell Proliferation by Inducing Beta-Catenin Signaling

research Cold atmospheric microwave plasma (CAMP) stimulates dermal papilla cell proliferation by inducing β-catenin signaling

February 2023 in “Scientific Reports”

Cold Atmospheric Microwave Plasma (CAMP) helps hair cells grow and could potentially treat hair loss.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Gene Expression Profiles of Melanocytes Over-Expressing miR-5110 in Alpaca

January 2026 in “Current Issues in Molecular Biology”

miR-5110 affects alpaca pigmentation by altering specific gene expressions.

research Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

58 citations , February 2013 in “Journal of Biological Chemistry”

LGR5 mainly stays inside cells, moving to the trans-Golgi network, and this process is important for its role in cell signaling.

research Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway

12 citations , November 2020 in “Molecules”

Carvone helps treat skin issues by reducing melanin and stopping harmful cell growth.