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Did you mean Cannabinoid Receptor Type 2?

GlossaryCannabinoid Receptor Type 2

protein involved in immune response and inflammation regulation

Cannabinoid Receptor Type 2 (CB2 receptor) is a protein found primarily in the immune system and peripheral tissues. It plays a crucial role in modulating inflammation and immune responses. Unlike its counterpart, the CB1 receptor, which is mainly located in the brain and central nervous system, CB2 receptors are less associated with psychoactive effects and are being studied for their potential therapeutic benefits in conditions like chronic pain, autoimmune diseases, and even hair growth disorders.

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research A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytesin vitroandin situ

66 citations , February 2013 in “PeerJ”

Activating cannabinoid receptor 1 reduces certain keratin levels, potentially aiding psoriasis treatment.

Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

research Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle

14 citations , February 2021 in “Experimental Dermatology”

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

research Peer Review #2 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

February 2013

Activating CB1 can reduce keratin levels, potentially helping manage psoriasis and aid wound healing.

research Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

February 2013

Activating cannabinoid receptor 1 may help manage psoriasis by reducing certain keratins.

17β-Estradiol May Control Human Hair Follicle Growth Also via Up-Regulating the Expression of Cannabinoid Receptor Type 1

research 1370 17β-estradiol may control human HF growth also via up-regulating the expression of cannabinoid receptor type1 expression

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.

research 438 Laminin-511 is a new player in the development of psoriasis and controlled via cannabinoid receptor type 1

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Laminin-511 is involved in psoriasis development and can be regulated by cannabinoid receptor type 1.

research Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual‐acting” (2 for 1) plant‐based peptides, hormones, and cannabinoids

13 citations , May 2021 in “FASEB bioAdvances”

Plant-based products can improve hair and skin health without harmful side effects.

research 1348 Involvement of mast cells and CB1 in the pathogenesis of IgA vasculitis

April 2023 in “Journal of Investigative Dermatology”

Mast cells and the CB1 receptor may be key in causing IgA vasculitis.

research Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases?

26 citations , May 2014 in “BioEssays”

Using neurohormones to control keratin can lead to new skin disease treatments.

research Stem Cells and their Niches

1 citations , January 2013 in “Journal of Investigative Dermatology”

The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.

research Neuroendocrine Controls of Keratin Expression in Human Skin

December 2018 in “IntechOpen eBooks”

Neurohormones help control skin health and could treat skin disorders.

research Theoretical Evaluation of Twenty-Cannabinoid Derivatives on Either Androgen Receptor or 5α-Reductase Enzyme

3 citations , January 2023 in “Clinical cancer investigation journal”

Some cannabinoid derivatives may be more effective than current drugs at targeting proteins relevant to prostate cancer treatment.

research Cannabinoids and Their Receptors in Skin Diseases

1 citations , November 2023 in “International journal of molecular sciences”

Cannabinoids might help treat skin problems but more research is needed to be sure.

research A Summary of Pre-Clinical and Clinical Evidence for Cannabinoid Hair Follicle Effects

January 2022 in “Clinical dermatology open access journal”

Certain cannabinoids may help increase hair growth and could be useful for treating hair loss.

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

142 citations , March 2019 in “Molecules/Molecules online/Molecules annual”

Cannabinoids may help treat various skin conditions.

research Endocannabinoids limit excessive mast cell maturation and activation in human skin

124 citations , January 2012 in “Journal of Allergy and Clinical Immunology”

Endocannabinoids help control mast cell activity in human skin.

research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

3 citations , December 2022 in “Cells”

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.

research Case Report: Alopecia Areata And Cannabis Use

March 2022 in “Research Square (Research Square)”

A girl with severe hair loss saw hair regrowth after using cannabis.

research Scientific Evidence for the Cosmetic Skin and Hair Benefits of Hemp-derived Cannabinoids: A Review

January 2024 in “Clinical dermatology open access journal”

Hemp-derived cannabinoids can benefit skin and hair without causing a high.

research Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain

50 citations , May 2019 in “Drugs”

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

research Targeting Cutaneous Cannabinoid Signaling in Inflammation - A “High”-way to Heal?

28 citations , January 2017 in “EBioMedicine”

Enhancing cannabinoid signaling may help treat skin inflammation.

The Impact of Cannabis Use on Local Anesthetic Dosing During Hair Restoration Surgery: A Case Report, Proposed Mechanisms, and Clinical Recommendations

research The impact of cannabis use on local anesthetic dosing during hair restoration surgery: a case report, proposed mechanisms, and clinical recommendations

March 2025 in “Journal of Dermatological Treatment”

Cannabis users may need higher anesthetic doses during hair restoration surgery.

research Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System

2 citations , January 2020 in “Evidence-based Complementary and Alternative Medicine”

Hataedock treatment improved skin health and reduced atopic dermatitis symptoms by enhancing the skin barrier and reducing inflammation.

research The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders

75 citations , August 2018 in “Biochemical pharmacology”

Targeting the skin's endocannabinoid system could help treat skin disorders.

research Unravelling a novel role for Cannabidivarin in the modulation of subventricular zone postnatal neurogenesis

May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Cannabidivarin (CBDV) helps new brain cells grow and develop in a specific brain area through a certain receptor.

Nicotinic Acid Suppresses Sebaceous Lipid Synthesis of Human Sebocytes via Activating Hydroxycarboxylic Acid Receptor 2 (HCA2)

research 1317 Nicotinic acid suppresses sebaceous lipid synthesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2)

April 2018 in “Journal of Investigative Dermatology”

Nicotinic acid reduces excessive oil production in skin cells by activating a specific receptor, which could help treat acne.

research Prenatal Exposure to Delta-9-tetrahydrocannabinol (THC) Alters the Expression of miR-122-5p and Its Target Igf1r in the Adult Rat Ovary

9 citations , July 2022 in “International Journal of Molecular Sciences”

Prenatal THC exposure may harm ovarian health and fertility.