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GlossaryNon-canonical Wnt Pathway

regulates cell movement and organization without using β-catenin

The Non-canonical Wnt Pathway is a signaling pathway that operates independently of the β-catenin protein, which is central to the canonical Wnt pathway. This pathway is involved in regulating various cellular processes such as cell movement and organization, and it includes sub-pathways like the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway. These pathways play crucial roles in embryonic development, tissue regeneration, and diseases, including certain types of alopecia.

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4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research XEDAR activates the non-canonical NF-κB pathway

18 citations , August 2015 in “Biochemical and Biophysical Research Communications”

XEDAR triggers a specific signaling pathway in cells.

research 0748 Synergy of TP53 and non-canonical sonic hedgehog pathway in the development of complex basal cell carcinoma

July 2025 in “Journal of Investigative Dermatology”

Complex basal cell carcinomas need personalized treatment due to unique genetic mutations.

research Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway

11 citations , October 2017 in “Oncotarget”

Gsdma3 affects hair growth by controlling Wnt5a, which influences hair cell development.

research Potential relationship between the canonical Wnt signalling pathway and expression of the vitamin D receptor in alopecia

21 citations , March 2014 in “Clinical and experimental dermatology”

Targeting the Wnt pathway might help treat hair loss.

Cthrc1 Deficiency Aggravates Wound Healing and Promotes Cardiac Rupture After Myocardial Infarction via Non-Canonical WNT5A Signaling Pathway

research Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway

9 citations , January 2023 in “International Journal of Biological Sciences”

CTHRC1 is essential for healing and preventing heart rupture after a heart attack.

Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

research Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells

July 2023 in “Current Issues in Molecular Biology”

Escin may help treat hair loss by boosting a specific cell growth pathway.

research Regulatory Processes of the Canonical Wnt/β-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair

11 citations , April 2022 in “International Journal of Molecular Sciences”

Understanding the Wnt/β-catenin pathway and photobiomodulation could improve diabetic wound healing.

research Abstract 1026: A non-apoptotic function for Mcl-1 as an activator of canonical Wnt signaling in keratinocytes

April 2010 in “Cancer Research”

Mcl-1 can activate Wnt signaling in skin cells, promoting growth and possibly cancer.

research The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration

2 citations , November 2023 in “Biomolecules”

WNT signaling is crucial for skin development and healing.

research Canonical and non-canonical Wnt signaling control the regeneration of amputated rodent vibrissae follicles

5 citations , January 2016 in “Journal of Molecular Histology”

Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.

research Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics

16 citations , February 2014 in “Journal of Investigative Dermatology”

Researchers developed a mouse model that tracks hair growth using bioluminescence, improving accuracy in studying hair cycles.

Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

research Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells

14 citations , November 2007 in “Journal of Dermatological Science”

Vitamin C derivative may promote hair growth by activating specific genes.

Wound Healing in Development: Mechanisms and Regulation

research Wound healing in development

29 citations , September 2012 in “Birth Defects Research”

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

research Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells

28 citations , February 2006 in “Biochemical and Biophysical Research Communications”

Wnt-10b helps skin cells and hair grow.

research The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development

16 citations , March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.

research Targeting of Smoothened for therapeutic gain

105 citations , April 2014 in “Trends in Pharmacological Sciences”

Targeting the Smoothened receptor shows promise for treating certain cancers.

Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia

95 citations , January 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

research Wnt signaling in skin organogenesis

72 citations , April 2008 in “Organogenesis”

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

research Wnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration

16 citations , January 2016 in “International Journal of Medical Sciences”

Wnt5a slows down hair growth by blocking a specific pathway during hair regeneration.

Wnt4 Increases the Thickness of the Epidermis in Burn Wounds by Activating Canonical Wnt Signalling and Decreasing Cell Junctions Between Epidermal Cells

research Wnt4 increases the thickness of the epidermis in burn wounds by activating canonical Wnt signalling and decreasing the cell junctions between epidermal cells

1 citations , January 2023 in “Burns & Trauma”

Wnt4 protein makes the outer skin layer thicker in burn wounds by turning on a specific healing pathway and loosening the connections between skin cells.

Baicalin Increases Hair Follicle Development by Enhancing Canonical Wnt/β-Catenin Signaling and Activating Dermal Papilla Cells in Mice

research Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice

23 citations , January 2018 in “International Journal of Molecular Medicine”

Baicalin helps hair growth by activating specific cell signals and pathways.

research Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury.

September 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Special gut cells help stem cells move to and fix injured areas by activating a specific signaling pathway.

research 877 Small T antigen from a folliculotropic polyomavirus activates canonical Wnt/β-catenin signaling in vivo

April 2017 in “Journal of Investigative Dermatology”

A virus protein can activate a pathway that may lead to abnormal hair follicle development.

research Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

293 citations , September 2004 in “Development”

WNT signaling is crucial for starting mammary gland development.

research Involvement of Wnt, Eda and Shh at defined stages of sweat gland development

55 citations , September 2014 in “Development”

Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.

research Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene

1 citations , February 2025 in “Journal of Dairy Science”

The SLICK1 allele in Holstein heifers affects hair and immune traits without altering prolactin signaling.

research Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems

21 citations , January 2023 in “The International Journal of Developmental Biology”

The Wnt signaling pathway is crucial for regeneration and could help advance human medicine.

research EMT Factors and Metabolic Pathways in Cancer

346 citations , April 2020 in “Frontiers in Oncology”

EMT and metabolic pathways help cancer cells resist treatment and spread.

research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

1 citations , May 2017 in “InTech eBooks”

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.