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GlossaryCaspase-9

enzyme initiating programmed cell death in response to damage

Caspase-9 is an enzyme that plays a crucial role in the process of apoptosis, which is the programmed cell death essential for maintaining healthy tissue and organ function. It is activated in response to cellular stress or damage and initiates a cascade of events leading to the orderly dismantling of the cell. This enzyme is also known as Apoptotic protease Mch-6 and is vital for preventing the accumulation of damaged or potentially cancerous cells.

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research Shen-Ying-Yang-Zhen formula promotes angiogenesis around hair follicles, alleviates oxidative stress, and inhibits hair follicle apoptosis through the VEGF/Akt/Caspase-9 signaling axis

June 2025 in “Phytomedicine”

The formula may improve hair growth and health by boosting blood flow and reducing cell stress.

Caspases in Life and Death: Their Role in Head Formation

research Making the head: Caspases in life and death

7 citations , January 2023 in “Frontiers in Cell and Developmental Biology”

Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.

research 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling

29 citations , March 2014 in “PloS one”

Astragaloside IV may help prevent hair loss by blocking a specific pathway that leads to cell death.

research Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration

25 citations , June 2021 in “Developmental Cell”

Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.

research Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

13 citations , September 2021 in “Current Issues in Molecular Biology”

Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.

Endocrinology and Metabolism News, August 2005: Effects of Finasteride on Benign Prostatic Hyperplasia Tissues

research Endocrinology & Metabolism News, August 2005

6 citations , August 2005 in “The Journal of Clinical Endocrinology & Metabolism”

Finasteride causes temporary cell death in BPH tissues.

research Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study

December 2024 in “International Journal of Molecular Sciences”

Platelet-rich fibrin may help reduce nonmelanoma skin cancer cell growth.

research 丹蒽醌對人類惡性黑色素瘤細胞株(A375.S2)誘發細胞週期停滯及細胞凋亡之影響

January 2008 in “中山醫學大學醫學研究所學位論文”

Danthron from Rhubarb causes melanoma cells to stop growing and die.

research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation

51 citations , March 2019 in “Experimental Dermatology”

Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.

research Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis

10 citations , January 2016 in “Planta Medica”

Formononetin, found in red clover plants, can promote hair regrowth and reduce hair loss by preventing cell death.

research Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss

9 citations , January 2018 in “BioMed Research International”

Tetrahydroxystilbene Glucoside may help prevent hair loss by blocking certain pathways that lead to cell death.

research <b>Platelet-rich plasma improves caspase-3 of skin graft treated with Tilapia Mozambique bio-dressing</b>

January 2025 in “Open Veterinary Journal”

PRP with TM bio-dressing improves skin graft healing in cats.

Non-Apoptotic Role for Caspase-7 in Hair Follicles and Surrounding Tissue

research Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

6 citations , August 2015 in “Journal of Molecular Histology”

Caspase-7 has functions in skin and hair that are not related to cell death.

research The effect of tripeptide-copper complex on human hair growth in vitro

39 citations , July 2007 in “Archives of Pharmacal Research”

A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.

research Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury

19 citations , February 2017 in “Journal of radiation research”

High-dose radiation speeds up aging in skin stem cells.

research Electric Stimulation at 448 kHz Modulates Proliferation and Differentiation of Follicle Dermal Papilla Cells

October 2024 in “Cosmetics”

Electric stimulation at 448 kHz can promote hair growth by enhancing cell activity in hair follicles.

research Inflammasome Proteins as Biomarkers of Injury and Disease

January 2014 in “Springer eBooks”

Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.

research Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth

7 citations , December 2008 in “Journal of Dermatological Science”

Progranulin overexpression leads to shorter, thinner hair and increased cell death in mouse hair follicles.

research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis

28 citations , September 1998 in “Journal of Investigative Dermatology”

Two distinct caspases in human skin help with cell death and skin formation.

Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

research Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways

12 citations , May 2019 in “Molecular Medicine Reports”

Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.

research Protective Effects of BCC Against Oxidative Stress in Cardiomyocyte Cells

March 2024 in “Journal of Experimental & Biomedical Sciences/Biomedical Science Letters”

BCC can protect heart cells from damage caused by oxidative stress.

research Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson’s Disease

17 citations , June 2023 in “Pharmaceuticals”

Inflammasome proteins may help diagnose and treat Parkinson's disease.

research Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

18 citations , October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

research The concealed side of caspases: beyond a killer of cells

13 citations , December 2024 in “Cellular and Molecular Life Sciences”

Caspases do more than kill cells; they also help in cell growth and disease, and targeting them could lead to new treatments.

research Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia

27 citations , March 2012 in “Dermatologic Surgery”

Higher caspase-1 levels found in balding scalps; reducing it may help treat hair loss.