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Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Epidermal keratinocytes start wound healing and inflammation after schistosome infection.

Notch1 helps skin heal by attracting cells that aid repair.

Notch1 helps skin heal by attracting specific immune cells.

Wasabi leaf extract affects gene expression in skin cells.

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

Genetic variants linked to ten skin diseases were found, showing both immune and non-immune factors play a role.

AP-2α and AP-2β proteins are essential for healthy adult skin and hair.

Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.

Lower GATA3 levels in mice help hair regrow by changing certain immune cells.

MCPIP1 in myeloid cells is important for skin cancer development and healthy hair growth.

Type 3 Innate Lymphoid Cells help maintain skin health and balance, and are involved in skin diseases and healing.

Keratinocytes contribute to hidradenitis suppurativa by causing inflammation and worsening the condition.

Understanding skin reactions to radiation has improved, helping to reduce injuries and prevent skin cancer.

Certain gene variations may increase the risk and severity of alopecia areata.

Bacteria in our hair can affect its health and growth, and studying these bacteria could help us understand hair diseases better.

Certain gene variations increase the risk of alopecia areata in Koreans.

Traditional Chinese medicinal foods may help manage long-term post-COVID symptoms.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

Botulinum toxin type A significantly reduces scalp psoriasis severity compared to placebo.

Blocking IL-17 can reduce skin inflammation in a mouse model of pityriasis rubra pilaris.

Bacteroides fragilis and Microbacterium sp. T32 may be linked to autoimmune activity in Hashimoto's thyroiditis and alopecia areata.

In vitro skin models are improving but still need more innovation to fully replicate human skin.

Adenosine receptors could be promising targets for treating inflammatory skin diseases like psoriasis.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.